Testing Moderator Tools... Please Ignore

Jorra

Zebrafish eye formation has long been a model for studying vertebrate organogenesis. Eye development begins in the late gastrula stage as retinal progenitor cells (RPCs) are specified in the eye field of the anterior neural plate. As forebrain cells converge to the midline for neurulation, lateral RPCs converge more slowly producing a wide eye field. After converging, RPCs then begin to evaginate to produce the optic vesicle (Rembold et al.). Several transcription factors have been determined to be necessary for proper eye formation. Mutations or knockout of one transcription factor in particular, Rx3, leads to anophthalmia in many different model organisms. Specifically in zebrafish rx3 mutants, the RPCs fail to evaginate from the midline to produce optic vesicles (Kennedy et al.). Rx3 has many downstream targets, but they have not all been researched in depth. Recently, Ig-domain protein Neurolin-like cell adhesion molecule (Nlcam) has been identified as a downstream target of Rx3 (Brown et al.). Nlcam is an evolutionary relative of neurolin, a member of the activated leukocyte cell adhesion molecule (Alcam) subfamily of Ig-domain proteins. Nlcam is widely expressed from the beginning of gastrulation to the end of somitogenesis. It is also weakly expressed in presomitic mesoderm during myogenesis. Both Nlcam and neurolin are expressed in neuronal cell and eye development (Mann, Hinits and Hughes). The Alcam family of proteins has been shown to participate in both hemophilic and heterophilic cell-cell adhesion. They have been shown to function in development of axons, cancer progression, and other developmental processes. The current study identifies Nlcam as a downstream product of Rx3 that regulates midline convergence of forebrain and RPCs (Brown et al.).

elcieloesazul

Hi. :glasses:

downsizinghoss

can I still lose weight if I eat back my friends' exercise calories also? I would hate to waste them

Ravenesque_

meep meep!!

LisaF1163

Hitchhiker: You heard of this thing, the 8-Minute Abs?
Ted: Yeah, sure, 8-Minute Abs. Yeah, the excercise video.
Hitchhiker: Yeah, this is going to blow that right out of the water. Listen to this: 7... Minute... Abs.
Ted: Right. Yes. OK, all right. I see where you're going.
Hitchhiker: Think about it. You walk into a video store, you see 8-Minute Abs sittin' there, there's 7-Minute Abs right beside it. Which one are you gonna pick, man?
Ted: I would go for the 7.
Hitchhiker: Bingo, man, bingo. 7-Minute Abs. And we guarantee just as good a workout as the 8-minute folk.
Ted: You guarantee it? That's - how do you do that?
Hitchhiker: If you're not happy with the first 7 minutes, we're gonna send you the extra minute free. You see? That's it. That's our motto. That's where we're comin' from. That's from "A" to "B".
Ted: That's right. That's - that's good. That's good. Unless, of course, somebody comes up with 6-Minute Abs. Then you're in trouble, huh?
(*Hitchhiker convulses*)
Hitchhiker: No! No, no, not 6! I said 7! Nobody's comin' up with 6. Who works out in 6 minutes? You won't even get your heart goin, not even a mouse on a wheel!
Ted: That - good point.
Hitchhiker: 7's the key number here! Think about it. 7-Elevens. 7 dwarves. 7, man, that's the number. 7 little chipmunks twirlin' on a branch, eatin' lots of sunflowers on my uncle's ranch. You know that old children's tale from the sea! It's like you're dreamin' about Gorgonzola cheese when it's clearly Brie time, baby! Step into my office.
Ted: Why?
Hitchhiker: 'Cause you're f***in' fired!

76tech

Zebrafish eye formation has long been a model for studying vertebrate organogenesis. Eye development begins in the late gastrula stage as retinal progenitor cells (RPCs) are specified in the eye field of the anterior neural plate. As forebrain cells converge to the midline for neurulation, lateral RPCs converge more slowly producing a wide eye field. After converging, RPCs then begin to evaginate to produce the optic vesicle (Rembold et al.). Several transcription factors have been determined to be necessary for proper eye formation. Mutations or knockout of one transcription factor in particular, Rx3, leads to anophthalmia in many different model organisms. Specifically in zebrafish rx3 mutants, the RPCs fail to evaginate from the midline to produce optic vesicles (Kennedy et al.). Rx3 has many downstream targets, but they have not all been researched in depth. Recently, Ig-domain protein Neurolin-like cell adhesion molecule (Nlcam) has been identified as a downstream target of Rx3 (Brown et al.). Nlcam is an evolutionary relative of neurolin, a member of the activated leukocyte cell adhesion molecule (Alcam) subfamily of Ig-domain proteins. Nlcam is widely expressed from the beginning of gastrulation to the end of somitogenesis. It is also weakly expressed in presomitic mesoderm during myogenesis. Both Nlcam and neurolin are expressed in neuronal cell and eye development (Mann, Hinits and Hughes). The Alcam family of proteins has been shown to participate in both hemophilic and heterophilic cell-cell adhesion. They have been shown to function in development of axons, cancer progression, and other developmental processes. The current study identifies Nlcam as a downstream product of Rx3 that regulates midline convergence of forebrain and RPCs (Brown et al.).

my good friend D. rerio

Jorra

Zebrafish eye formation has long been a model for studying vertebrate organogenesis. Eye development begins in the late gastrula stage as retinal progenitor cells (RPCs) are specified in the eye field of the anterior neural plate. As forebrain cells converge to the midline for neurulation, lateral RPCs converge more slowly producing a wide eye field. After converging, RPCs then begin to evaginate to produce the optic vesicle (Rembold et al.). Several transcription factors have been determined to be necessary for proper eye formation. Mutations or knockout of one transcription factor in particular, Rx3, leads to anophthalmia in many different model organisms. Specifically in zebrafish rx3 mutants, the RPCs fail to evaginate from the midline to produce optic vesicles (Kennedy et al.). Rx3 has many downstream targets, but they have not all been researched in depth. Recently, Ig-domain protein Neurolin-like cell adhesion molecule (Nlcam) has been identified as a downstream target of Rx3 (Brown et al.). Nlcam is an evolutionary relative of neurolin, a member of the activated leukocyte cell adhesion molecule (Alcam) subfamily of Ig-domain proteins. Nlcam is widely expressed from the beginning of gastrulation to the end of somitogenesis. It is also weakly expressed in presomitic mesoderm during myogenesis. Both Nlcam and neurolin are expressed in neuronal cell and eye development (Mann, Hinits and Hughes). The Alcam family of proteins has been shown to participate in both hemophilic and heterophilic cell-cell adhesion. They have been shown to function in development of axons, cancer progression, and other developmental processes. The current study identifies Nlcam as a downstream product of Rx3 that regulates midline convergence of forebrain and RPCs (Brown et al.).

my good friend D. rerio

Pretty awesome, right? Best vertebrate model organism ever.

couponfun

Dolphins: [singing] So long, and thanks for all the fish
So sad that it should come to this
We tried to warn you all, but, oh, dear
You may not share out intellect
Which might explain your disrespect
For all the natural wonders that grow around you

So long, so long, and thanks for all the fish! The world's about to be destroyed
There's no point getting all annoyed
Lie back and let the planet dissolve around you
Despite those nets of tuna fleets
We thought that most of you were sweet
Especially tiny tots and your pregnant women

So long, so long, so long, so long, so long! So long, so long, so long, so long, so long! So long, so long, and thanks for all the fish!/ If I had just one last wish
I would like a tasty fish!
If we could just change one thing
We would all have learnt to sing!
Come one and all
Man and mammal
Side by side
In life's great gene pool!

So long, so long, so long, so long, so long
So long, so long, so long, so long
So long, so long and thanks for all the fish!

-- The Hitchhiker's Guide to the Galaxy

trud72

Do moderators have TOOLS then???? lol :devil:

couponfun

[As Lone Starr is about to push the self-destruct button, Dark Helmet appears.]
Dark Helmet: Not so fast, Lone Starr!
Lone Starr: Helmet. So, at last we meet for the first time for the last time. (Thinks about what he has just said, then nods in approval.)
Dark Helmet: Before you die, there is something you should know about us, Lone Starr.
Lone Starr: What?
Dark Helmet: I am your father's brother's nephew's cousin's former roommate.
Lone Starr: ... What's that make us?
Dark Helmet: Absolutely nothing, which is what you are about to become. Prepare to die.

-- Spaceballs

MassiveDelta

If your "testing" your tools you might find these beneficial

k2quiere

If your "testing" your tools you might find these beneficial

Perfect!

ninerbuff

$&(#&(*&%_+)

Is it working?

EmCarroll1990

****.

Edit: Nope, still can't swear on here.

couponfun

Four Horsemen of the Apocalypse recipe

1/2 oz Johnnie Walker® Black Label Scotch whisky
1/2 oz Jose Cuervo® Especial gold tequila
1/2 oz Jack Daniel's® Old No.7 Tennessee whiskey
1/2 oz Jim Beam® bourbon whiskey
1/2 oz Jagermeister® herbal liqueur
1 oz pineapple juice
2 oz sweet and sour mix

Pour all liqueurs into a cocktail shaker half-filled with ice. Shake until frosted. Strain into a highball glass filled with ice cubes and add pineapple juice and sweet and sour. Stir, and serve.

MassiveDelta

FLAMIN' BEAVER

1.5 oz. Fireball Cinnamon Whisky
Woodchuck Cider®
In a shot, in a drink- It's up to you

tobafa

How to make cat float after it's dead.

tobafa

1 dead cat
2 scoops of ice cream
10 oz of root beer

And you thought it was going to be something else didn't you....?

FunkyGranolaTree

1 dead cat
2 scoops of ice cream
10 oz of root beer

And you thought it was going to be something else didn't you....?

Is that low cal???

tobafa

1 dead cat
2 scoops of ice cream
10 oz of root beer

And you thought it was going to be something else didn't you....?

Is that low cal???

I suppose with low fat/sugar free ice cream and diet root beer anything's possible...

FunkyGranolaTree

1 dead cat
2 scoops of ice cream
10 oz of root beer

And you thought it was going to be something else didn't you....?

Is that low cal???

I suppose with low fat/sugar free ice cream and diet root beer anything's possible...

And just thinking out loud... it must be high fiber too!!! Can you whip me up one?

tobafa

1 dead cat
2 scoops of ice cream
10 oz of root beer

And you thought it was going to be something else didn't you....?

Is that low cal???

I suppose with low fat/sugar free ice cream and diet root beer anything's possible...

And just thinking out loud... it must be high fiber too!!! Can you whip me up one?

If my wife's cat wakes me up at 3AM again wanting food, I might just do that... :explode:

MassiveDelta

1 dead cat
2 scoops of ice cream
10 oz of root beer

And you thought it was going to be something else didn't you....?

Is that low cal???

I suppose with low fat/sugar free ice cream and diet root beer anything's possible...

And just thinking out loud... it must be high fiber too!!! Can you whip me up one?

If my wife's cat wakes me up at 3AM again wanting food, I might just do that... :explode:

I wouldnt cats are high in cholesterol

LisaF1163

But the fur and whiskers must be full of fiber!