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Is the Insulin Theory of Obesity Over?

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  • Posts: 38,459 MFP Moderator
    tlflag1620 wrote: »

    Also fructose.

    So avoid fruit?
  • Posts: 1,358 Member
    J72FIT wrote: »

    Disagree...

    Fructose is processed by the liver, being converted to glycogen and triglycerides. What type of "fatty foods" are taxing on the liver (there are lots of different types of fats)?

  • Posts: 18 Member
    tlflag1620 wrote: »

    I find it all very interesting too :)

    I do think having more availability probably leads us to perceive hunger more often, and perhaps more acutely (out of sight, out of mind, right?). But within the constraints of the same level of food availability, I think the breakdown of the diet can have significant impact; at least it has in my case. Food is every bit as available to me as it was when I was eating lower fat - I keep plenty of easy LC compliant foods on hand (right now there are a dozen hard boiled eggs in the fridge, some leftover roast chicken, washed and chopped salad greens and veggies, frozen berries, and roasted cashews - if I was hungry I could easily put together a meal or snack); I've learned to navigate being out and about while keeping LC (convenience stores have jerky and nuts, fast food places offer side salads you can sub instead of fries and it's easy enough to ditch the bun from the sandwich, pizza places almost universally have chicken wings and salads, regular sit-down restaraunts are super easy - order a simply cooked meat/chicken/fish, get two veggie sides instead of a starch and veggie, done). My reduced appetite is most certainly physical, not psychological. Especially after three years of doing this; I understand that some people may eat less at first simply because they haven't adapted to a new way of eating, but I've defiantly adapted :).

    Having "rules" (I don't eat that, I do eat this) probably does make it easier to say no to certain things, or at least to keep those items occasional. Myself, I don't eat wheat as a general rule. So yes, it is easy to pass on the breadsticks or pasta. But I do indulge now and then. I think what is most striking to me is that, with my appetite reduced and eating a more satiating diet overall, I find those occasional indulgences don't trip me up anymore. In my low fat days I'd allow myself occasional "cheats" too, but I found it much harder to control myself when doing that; I'd end up eating more of the treat than I should have, feel bad/guilty, find that I would be up a couple lbs the next day, but it would take a week or longer to get back down, which was demoralizing. Now, on LCHF, I can have those occasional indulgences, exercise true moderation (feeling in control feels good!) and while I will still be up a lb or two the next day, I find it drops back off in a day or two (rather than a week or two), so I stay motivated.

    Anywho... I'm rambling now. One last thing - I don't think IR is necessarily about carb percentage, so much as it is genetic (I have a strong family history of type 2 diabetes, so I'm fairly confident IR plays a role in how well I do on any given diet). In cultures with a high carb traditional diet, IR would pose a problem (overeating, never feeling full, getting overweight, etc). Those with IR in a high carb society may have ended up not being able to pass on their genes. Where as those with IR in a culture that eats lower carb would have done just fine. That's why I wonder if there are racial or ethnic variations wrt the rates of IR in different populations.

    Did you see that sugar film? Horrifying what high carb processed foods have done to indigenous people in Australia. It's a similar story in the United States. Rates of obesity related diseases are very high in the indigenous populations.
  • Posts: 38,459 MFP Moderator
    jquizzle10 wrote: »

    Did you see that sugar film? Horrifying what high carb processed foods have done to indigenous people in Australia. It's a similar story in the United States. Rates of obesity related diseases are very high in the indigenous populations.

    Do you realize those same high carb processed foods also contain a ton of fat? With the exception of candy, most processed foods have multiple nutrients. Targeting sugar when is the trend today.

    The take-a-way... eat more whole nutrient dense foods and less ultra processed foods.
  • Posts: 1,358 Member
    psulemon wrote: »

    So avoid fruit?

    Should I avoid fat? "Fatty foods" (whatever the hell that means) are not necessarily "taxing" on the liver - the type of fat matters. NAFLD is strongly linked to overconsumption of carbs, especially fructose. The modest amounts found in reasonable quantities of fruit probably don't pose a problem. But the alarming amounts found in soda and other heavily processed foods is concerning. Want to be kind to your liver? Avoid alcohol, cigarettes, fructose, omega 6 fats, and trans fats. (Note I said avoid, not necessarily eliminate, through in the case of cigarettes and trans fats, eliminate is probably sound advice!)

  • Posts: 18 Member
    psulemon wrote: »

    Do you realize those same high carb processed foods also contain a ton of fat? With the exception of candy, most processed foods have multiple nutrients. Targeting sugar when is the trend today.

    The take-a-way... eat more whole nutrient dense foods and less ultra processed foods.

    Are you suggesting fat consumption contributes to diabetes? I've never seen any compelling evidence to suggest this. In fact is contrary to everything I learned from biochemistry and cellular biology to human physiology. Show me some mechanistic explanation based in accepted physiology and I'll look into it.
  • Posts: 6,057 Member
    tlflag1620 wrote: »

    Fructose is processed by the liver, being converted to glycogen and triglycerides. What type of "fatty foods" are taxing on the liver (there are lots of different types of fats)?

    Fructose is one of the best at re-feuling liver glycogen...
  • Posts: 6,057 Member
    Yet another thread of analysis paralysis...
  • Posts: 1,358 Member
    J72FIT wrote: »

    Fructose is one of the best at re-feuling liver glycogen...

    And if liver glycogen is already full?

    Oh yeah, what "fatty food" are we supposed to be avoiding? Are all fats harmful to the liver? Never got an answer to that...

  • Posts: 6,057 Member
    tlflag1620 wrote: »

    And if liver glycogen is already full?

    Oh yeah, what "fatty food" are we supposed to be avoiding? Are all fats harmful to the liver? Never got an answer to that...

    Well if liver glycogen is already full then you don't chug a soda. What do you want me to say? Use common sense. Fructose is fine, a boatload of fructose is probably not fine. A boatload of anything (including fat)is probably not fine.

  • Posts: 38,459 MFP Moderator
    jquizzle10 wrote: »

    Are you suggesting fat consumption contributes to diabetes? I've never seen any compelling evidence to suggest this. In fact is contrary to everything I learned from biochemistry and cellular biology to human physiology. Show me some mechanistic explanation based in accepted physiology and I'll look into it.

    As already stated, obesity, inactivity and genetics are linked to diabetes. Macronutrients are not.
  • Posts: 38,459 MFP Moderator
    J72FIT wrote: »

    Well if liver glycogen is already full then you don't chug a soda. What do you want me to say? Use common sense. Fructose is fine, a boatload of fructose is probably not fine. A boatload of anything (including fat)is probably not fine.

    Considering it's probably full at surplus levels, you have bigger issue than fructose.
  • Posts: 532 Member
    J72FIT wrote: »

    Disagree...

    I'm not really sure how fatty foods hurt the liver. I've never heard that one! Fatty acids can circulate freely in the blood and can be used by all over the body. Fructose cannot. No body tissue can utilize it. It can only be broken down by the liver.
  • Posts: 38,459 MFP Moderator

    I'm not really sure how fatty foods hurt the liver. I've never heard that one! Fatty acids can circulate freely in the blood and can be used by all over the body. Fructose cannot. No body tissue can utilize it. It can only be broken down by the liver.

    Why does it matter where it's broken down? It still is converted to glucose. Your liver has many functions and that happens to be one of them.
  • Posts: 1,358 Member
    J72FIT wrote: »

    Well if liver glycogen is already full then you don't chug a soda. What do you want me to say? Use common sense. Fructose is fine, a boatload of fructose is probably not fine. A boatload of anything (including fat)is probably not fine.

    That's fair enough. You had suggested that if people want to take care of their livers, they should avoid alcohol and cigarettes (sound advice), but then mentioned avoiding "fatty foods" (which fatty foods? French fries and cookies, or salmon and avocados? The world may never know), but never mentioned sugars, especially fructose, which is strongly linked to NAFLD, because of the way it is metabolized. Some fats are hard on the liver, especially in excess. Some sugars are hard on the liver, especially in excess. Banal generalities about avoiding either "fatty" or "sugary" foods are pretty useless.

  • Posts: 38,459 MFP Moderator
    tlflag1620 wrote: »

    That's fair enough. You had suggested that if people want to take care of their livers, they should avoid alcohol and cigarettes (sound advice), but then mentioned avoiding "fatty foods" (which fatty foods? French fries and cookies, or salmon and avocados? The world may never know), but never mentioned sugars, especially fructose, which is strongly linked to NAFLD, because of the way it is metabolized. Some fats are hard on the liver, especially in excess. Some sugars are hard on the liver, especially in excess. Banal generalities about avoiding either "fatty" or "sugary" foods are pretty useless.

    No less useless than avoiding fructose (btw, when I hear fructose, I think fruits, not HFCS or processed foods). Why? Because we must look at things in context.
  • Posts: 532 Member
    psulemon wrote: »

    Why does it matter where it's broken down? It still is converted to glucose. Your liver has many functions and that happens to be one of them.

    Just do a simple google search, you will find plenty of information on the effects of excess fructose on the liver. Obviously the liver can only handle so much of a toxin.

    The entry of fructose into the liver kicks off a series of complex chemical transformations. (You can see a diagram of these at health.harvard.edu/172.) One remarkable change is that the liver uses fructose, a carbohydrate, to create fat. This process is called lipogenesis. Give the liver enough fructose, and tiny fat droplets begin to accumulate in liver cells (see figure). This buildup is called nonalcoholic fatty liver disease, because it looks just like what happens in the livers of people who drink too much alcohol.

    Virtually unknown before 1980, nonalcoholic fatty liver disease now affects up to 30% of adults in the United States and other developed countries, and between 70% and 90% of those who are obese or who have diabetes.

    Early on, nonalcoholic fatty liver disease is reversible. At some point, though, the liver can become inflamed. This can cause the low-grade damage known as nonalcoholic steatohepatitis (steato meaning fat and hepatitis meaning liver inflammation). If the inflammation becomes severe, it can lead to cirrhosis — an accumulation of scar tissue and the subsequent degeneration of liver function.


    http://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart
  • Posts: 1,358 Member
    psulemon wrote: »

    No less useless than avoiding fructose (btw, when I hear fructose, I think fruits, not HFCS or processed foods). Why? Because we must look at things in context.

    Which was kind of what I was getting at with my comment. I guess I should have said "avoid sugary foods" because fructose is a type of sugar that when consumed in excess can be bad for liver health, and "sugary foods" is just as vague as "fatty foods". But just as not all types of sugar are bad for the liver, not all types of fat are bad for the liver. And I don't see why one would advise others to avoid fatty foods (for liver health), but fail to mention sugary foods....

  • Posts: 38,459 MFP Moderator

    Just do a simple google search, you will find plenty of information on the effects of excess fructose on the liver. Obviously the liver can only handle so much of a toxin.

    The entry of fructose into the liver kicks off a series of complex chemical transformations. (You can see a diagram of these at health.harvard.edu/172.) One remarkable change is that the liver uses fructose, a carbohydrate, to create fat. This process is called lipogenesis. Give the liver enough fructose, and tiny fat droplets begin to accumulate in liver cells (see figure). This buildup is called nonalcoholic fatty liver disease, because it looks just like what happens in the livers of people who drink too much alcohol.

    Virtually unknown before 1980, nonalcoholic fatty liver disease now affects up to 30% of adults in the United States and other developed countries, and between 70% and 90% of those who are obese or who have diabetes.

    Early on, nonalcoholic fatty liver disease is reversible. At some point, though, the liver can become inflamed. This can cause the low-grade damage known as nonalcoholic steatohepatitis (steato meaning fat and hepatitis meaning liver inflammation). If the inflammation becomes severe, it can lead to cirrhosis — an accumulation of scar tissue and the subsequent degeneration of liver function.


    http://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart

    And if you read the whole thing: Still, it’s worth cutting back on fructose. But don’t do it by giving up fruit. Fruit is good for you and is a minor source of fructose for most people. The big sources are refined sugar and high-fructose corn syrup

    Essentially, give us junk food. Not mind blowing researching.


    This also takes into consideration the average person, which in America is eating too little fruit, too much soda and is not active at all.
  • Posts: 1,358 Member
    Fructose is converted to glucose and triglycerides. Overconsumption is linked to NAFLD. There has been a large increase in NAFLD in recent years, especially among children (it used to be something rarely seen outside old age). Perhaps the largest source of fructose in the American diet is not fruit, but soda and other sweetened beverages. So advising people to help their liver by avoiding "fatty foods" is not exactly common sense. Soda is now, and has always been, a fat free food.
  • Posts: 6,057 Member
    psulemon wrote: »

    Pretty much anything is excess is not good. Which is why I am baffled at the comments over the past few pages. We are over complicating this.

    ^^^^This....
  • Posts: 1,358 Member
    psulemon wrote: »

    There are more diseases that just NAFLD. Only being concerned with one, but not others is a bit short sighted, IMO. High calorie, low nutrient foods, can contribute to weight gain, which can lead to diabetes, cvd, IR, and so much more.

    The comment I responded to was specifically talking about liver health. Avoiding "fatty foods" (still don't know what "fatty foods" we are talking about - that was never mentioned) is pretty useless advice. And why demonize fats as being "hard" on the liver without also mentioning how sugar can be hard on the liver?
  • Posts: 30,886 Member

    I'm a stay at home mom and have access to all sorts of food, all the time, and it's really not an issue for me? I bought my daughter a donut this morning at the grocery store when I was there, but it didn't even cross my mind to get myself a donut because I hadn't factored it into my calorie plan for the day. And that's how I interact with food at home as well. Maybe I really am a weird freak snowflake :p

    No, I don't think so. What I'm saying is that being successful in these kinds of environment requires some sort of plan or strategy for many of us (those of us who have become overweight, probably, and likely many who simply prevented themselves from doing so). The point I was trying to make is that there are many different avenues to do so that work better or worse for different people. Counting calories and not changing diet is certainly one, as is planning ahead and eating based on plan. Some people perceive that as a constant struggle against what they want, whereas others take to it and find it fun. (I did, along with some other strategies, sounds like you do.)
  • Posts: 2,577 Member
    tlflag1620 wrote: »
    One last thing - I don't think IR is necessarily about carb percentage, so much as it is genetic (I have a strong family history of type 2 diabetes, so I'm fairly confident IR plays a role in how well I do on any given diet). In cultures with a high carb traditional diet, IR would pose a problem (overeating, never feeling full, getting overweight, etc). Those with IR in a high carb society may have ended up not being able to pass on their genes. Where as those with IR in a culture that eats lower carb would have done just fine. That's why I wonder if there are racial or ethnic variations wrt the rates of IR in different populations.
    I think that does make sense, as I do think genetics plays a role. So I would think from that standpoint it could be said that genetics can set a lower bound for how many carbs a given person can tolerate.

  • Posts: 6,057 Member
    tlflag1620 wrote: »

    The comment I responded to was specifically talking about liver health. Avoiding "fatty foods" (still don't know what "fatty foods" we are talking about - that was never mentioned) is pretty useless advice. And why demonize fats as being "hard" on the liver without also mentioning how sugar can be hard on the liver?

    Hydrogenated vegetable oils for one. Eliminate completely? No, not necessary. Moderate consumption, yes. But that goes for most things.
  • Posts: 1,358 Member
    psulemon wrote: »

    And if you read the whole thing: Still, it’s worth cutting back on fructose. But don’t do it by giving up fruit. Fruit is good for you and is a minor source of fructose for most people. The big sources are refined sugar and high-fructose corn syrup

    Essentially, give us junk food. Not mind blowing researching.


    This also takes into consideration the average person, which in America is eating too little fruit, too much soda and is not active at all.

    No one ever said to give up or avoid fruit (I addressed that earlier when you asked). Why hasn't anyone addressed the whole "fatty food" comment? When I think of fatty foods I think of whole eggs, salmon, seeds and nuts, avocados, olive oil, butter, cheese, dark meat chicken... Or was J72FIT referring to "fatty foods" like packaged cookies and snack cakes, potato chips, and other junk foods (and what of fat free sodas and sports drinks)? In that case why didn't he say, avoid junk food? Why hate on fatty foods?

This discussion has been closed.