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The Sugar Conspiracy
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pcoslady83 wrote: »stevencloser wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
I hope I've been clear that I think it's more nuanced than just a willpower problem and calling something psychological is in no way a dismissal. If someone tells me they really struggle with sugar I am in no position to say "No you don't get a grip" but can discuss how to categorise it or whether it's the substance itself.
A simple google search will point you to papers. Here is the first link that turned up and I have copied the conclusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/
The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse. According to the evidence in rats, intermittent access to sugar and chow is capable of producing a “dependency”. This was operationally defined by tests for bingeing, withdrawal, craving and cross-sensitization to amphetamine and alcohol. The correspondence to some people with binge eating disorder or bulimia is striking, but whether or not it is a good idea to call this a “food addiction” in people is both a scientific and societal question that has yet to be answered. What this review demonstrates is that rats with intermittent access to food and a sugar solution can show both a constellation of behaviors and parallel brain changes that are characteristic of rats that voluntarily self-administer addictive drugs. In the aggregrate, this is evidence that sugar can be addictive.
Now..please don't tell me that the study was in rats and not applicable to humans.
Why would I not tell you that? The study is literally on rats. This has been discussed already. http://blogs.scientificamerican.com/brainwaves/is-sugar-really-toxic-sifting-through-the-evidence/ Rat study dealt with in this article.
Sure..I did go through the article. I found two places where it mentions rat study.
<snip>
B. Not only do many worrying fructose studies use unrealistic doses of the sugar unaccompanied by glucose, it also turns out that the rodents researchers have studied metabolize fructose in a very different way than people do—far more different than originally anticipated. Studies that have traced fructose's fantastic voyage through the human body suggest that the liver converts as much as 50 percent of fructose into glucose, around 30 percent of fructose into lactate and less than one percent into fats. In contrast, mice and rats turn more than 50 percent of fructose into fats, so experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance.
<snip>
Now..for B. Sure liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat. I have a hard time understanding what is the point the author is trying to make here.
I think your point A has been well covered by other posters. I'd like to address point B.
The paragraph you've quoted here contains two points which go hand in hand in order to reach a conclusion. These are: a human liver would convert as much as 50% of that fructose into glucose; a rat liver would convert more than 50% of it into fat.
We'll add to these facts a third one that you provided:[a human] liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat.
Please bear with me as I piece this together.
As you correctly stated, in a human excess glucose is converted to fat; so then at first glance those aforementioned figures of 50% might appear to be equivalent.
However, please pay close attention to the wording here. It is the excess glucose that is converted into fat, and a human liver may convert as much as 50% of fructose into glucose. Let's use 50 grams of straight fructose, ingested by Alice, as an example to illustrate what I'm trying to say. As much as 25 grams of it could be converted to glucose. How much of that is excess? Of course that would depend on how much glucose Alice's body needs, so it is quite possible that less than 25 grams of the recently-converted glucose is re-converted into fat.
As for a rat or mouse liver, again please pay close attention to the wording. "Mice and rats turn more than 50% of fructose into fats." Returning to our illustration, let's say that Bob the lab rat is fed 50 grams of straight fructose (we're keeping Alice's and Bob's amounts the same only for the sake of simplicity & comparison). Over 25 grams could be converted into fat for poor Bob.
Do you see the subtle yet important difference that could make mouse and rat studies unreliable when extrapolated to humans?
Regarding your point that excess glucose is a "problem in addiction like behavior with sugar causes", here we agree. Excess glucose is a problem. No one says it's OK to consume any form of sugar to the point that your liver begins to turn it to fat; and I would like to see more help available for people who, for whatever reason, engage in addiction-like or compulsive behavior when it comes to food.
Let us consider you argument and take a can of classic coke which is just sugar (so that we don't have fat or any protein or complex carbohydrates coming into equation and a can of coke is something many people consume). Google says it has 39 grams of sugar. Let us say 25% of that get converted to fat which is roughly 10 grams fat per day which is 8 pounds per year and I don't think it is less.
Also, again I restate my my point that many people may not stop at one coke or one cookie or one slice of cake because sugar makes you eat more of it.
Right. But a rat study could potentially show that those 39 grams of sugar (let's say it's all fructose to keep it consistent) convert to as much as 19.5 grams of fat or more because, as the article said, "mice and rats turn more than 50 percent of fructose into fats"; whereas a human " liver converts as much as 50 percent of fructose into glucose", (in the case of the Coke, 19.5 grams or less which then may or may not turn into fat).
This highlights why it can be inaccurate to extrapolate and apply data gathered from rat studies to humans. The author said "experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance." And you said you had a hard time understanding why that would be, and I've attempted to explain.
Again, I agree with your point that many people may not stop after just one because of many reasons. That is unhealthy no matter how you look at it and I'd like to see more help available to people who display compulsive eating habits.
Sure...we applied a correction to compensate for the exaggeration that the article claims and we see it is still a huge impact. So just because he is claiming that differences are exaggerated, it still doesn't mean the impact of sugar on human beings is insignificant. So that argument is not worth much.
Oh OK. Do you know where I can read about that? I'm actually very curious about the validity of rodent studies as applied to humans. I asked a question yesterday about it and didn't get an answer. It would make a huge difference if a correction had been applied to compensate for the differences, and I would have to repent in dust and sack cloth.
We applied the correction you suggested right here for the most reasonable case of a can of coke using the numbers provided by the article and using a liberal estimate that only half of glucose resulting from fructose gets to fats.
Here is a paper where Dr. Lustig answers your question.
http://ac.els-cdn.com/S0002822310019851/1-s2.0-S0002822310019851-main.pdf?_tid=6fc801d8-20a9-11e6-89cf-00000aacb35f&acdnat=1463982457_96671721f8e69b58feaecfc74bea0c9f
Anyways..when claiming exaggeration, Scientific American post refers to a paper which doesn't compare mice and human beings at all. I have no clue where he got the data from. Can you please point me where I can find the information about rats converting 50% of fructose to fat?
And I am getting out of here. It was fun debating with you all.
Please, no Lustig. He's as credible as the guy with the ancient aliens.
Well..you can have your opinions.
The irony is we are debating about an article that heavily relies on Lustig's work and you don't want to quote him.
It's not a personal preference. Lustig isn't credible. Credibility isn't a fashion or opinion.9 -
This is the link to the fructose study you've been asking for though http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-9-891
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paulgads82 wrote: »pcoslady83 wrote: »stevencloser wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
I hope I've been clear that I think it's more nuanced than just a willpower problem and calling something psychological is in no way a dismissal. If someone tells me they really struggle with sugar I am in no position to say "No you don't get a grip" but can discuss how to categorise it or whether it's the substance itself.
A simple google search will point you to papers. Here is the first link that turned up and I have copied the conclusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/
The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse. According to the evidence in rats, intermittent access to sugar and chow is capable of producing a “dependency”. This was operationally defined by tests for bingeing, withdrawal, craving and cross-sensitization to amphetamine and alcohol. The correspondence to some people with binge eating disorder or bulimia is striking, but whether or not it is a good idea to call this a “food addiction” in people is both a scientific and societal question that has yet to be answered. What this review demonstrates is that rats with intermittent access to food and a sugar solution can show both a constellation of behaviors and parallel brain changes that are characteristic of rats that voluntarily self-administer addictive drugs. In the aggregrate, this is evidence that sugar can be addictive.
Now..please don't tell me that the study was in rats and not applicable to humans.
Why would I not tell you that? The study is literally on rats. This has been discussed already. http://blogs.scientificamerican.com/brainwaves/is-sugar-really-toxic-sifting-through-the-evidence/ Rat study dealt with in this article.
Sure..I did go through the article. I found two places where it mentions rat study.
<snip>
B. Not only do many worrying fructose studies use unrealistic doses of the sugar unaccompanied by glucose, it also turns out that the rodents researchers have studied metabolize fructose in a very different way than people do—far more different than originally anticipated. Studies that have traced fructose's fantastic voyage through the human body suggest that the liver converts as much as 50 percent of fructose into glucose, around 30 percent of fructose into lactate and less than one percent into fats. In contrast, mice and rats turn more than 50 percent of fructose into fats, so experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance.
<snip>
Now..for B. Sure liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat. I have a hard time understanding what is the point the author is trying to make here.
I think your point A has been well covered by other posters. I'd like to address point B.
The paragraph you've quoted here contains two points which go hand in hand in order to reach a conclusion. These are: a human liver would convert as much as 50% of that fructose into glucose; a rat liver would convert more than 50% of it into fat.
We'll add to these facts a third one that you provided:[a human] liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat.
Please bear with me as I piece this together.
As you correctly stated, in a human excess glucose is converted to fat; so then at first glance those aforementioned figures of 50% might appear to be equivalent.
However, please pay close attention to the wording here. It is the excess glucose that is converted into fat, and a human liver may convert as much as 50% of fructose into glucose. Let's use 50 grams of straight fructose, ingested by Alice, as an example to illustrate what I'm trying to say. As much as 25 grams of it could be converted to glucose. How much of that is excess? Of course that would depend on how much glucose Alice's body needs, so it is quite possible that less than 25 grams of the recently-converted glucose is re-converted into fat.
As for a rat or mouse liver, again please pay close attention to the wording. "Mice and rats turn more than 50% of fructose into fats." Returning to our illustration, let's say that Bob the lab rat is fed 50 grams of straight fructose (we're keeping Alice's and Bob's amounts the same only for the sake of simplicity & comparison). Over 25 grams could be converted into fat for poor Bob.
Do you see the subtle yet important difference that could make mouse and rat studies unreliable when extrapolated to humans?
Regarding your point that excess glucose is a "problem in addiction like behavior with sugar causes", here we agree. Excess glucose is a problem. No one says it's OK to consume any form of sugar to the point that your liver begins to turn it to fat; and I would like to see more help available for people who, for whatever reason, engage in addiction-like or compulsive behavior when it comes to food.
Let us consider you argument and take a can of classic coke which is just sugar (so that we don't have fat or any protein or complex carbohydrates coming into equation and a can of coke is something many people consume). Google says it has 39 grams of sugar. Let us say 25% of that get converted to fat which is roughly 10 grams fat per day which is 8 pounds per year and I don't think it is less.
Also, again I restate my my point that many people may not stop at one coke or one cookie or one slice of cake because sugar makes you eat more of it.
Right. But a rat study could potentially show that those 39 grams of sugar (let's say it's all fructose to keep it consistent) convert to as much as 19.5 grams of fat or more because, as the article said, "mice and rats turn more than 50 percent of fructose into fats"; whereas a human " liver converts as much as 50 percent of fructose into glucose", (in the case of the Coke, 19.5 grams or less which then may or may not turn into fat).
This highlights why it can be inaccurate to extrapolate and apply data gathered from rat studies to humans. The author said "experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance." And you said you had a hard time understanding why that would be, and I've attempted to explain.
Again, I agree with your point that many people may not stop after just one because of many reasons. That is unhealthy no matter how you look at it and I'd like to see more help available to people who display compulsive eating habits.
Sure...we applied a correction to compensate for the exaggeration that the article claims and we see it is still a huge impact. So just because he is claiming that differences are exaggerated, it still doesn't mean the impact of sugar on human beings is insignificant. So that argument is not worth much.
Oh OK. Do you know where I can read about that? I'm actually very curious about the validity of rodent studies as applied to humans. I asked a question yesterday about it and didn't get an answer. It would make a huge difference if a correction had been applied to compensate for the differences, and I would have to repent in dust and sack cloth.
We applied the correction you suggested right here for the most reasonable case of a can of coke using the numbers provided by the article and using a liberal estimate that only half of glucose resulting from fructose gets to fats.
Here is a paper where Dr. Lustig answers your question.
http://ac.els-cdn.com/S0002822310019851/1-s2.0-S0002822310019851-main.pdf?_tid=6fc801d8-20a9-11e6-89cf-00000aacb35f&acdnat=1463982457_96671721f8e69b58feaecfc74bea0c9f
Anyways..when claiming exaggeration, Scientific American post refers to a paper which doesn't compare mice and human beings at all. I have no clue where he got the data from. Can you please point me where I can find the information about rats converting 50% of fructose to fat?
And I am getting out of here. It was fun debating with you all.
Please, no Lustig. He's as credible as the guy with the ancient aliens.
Well..you can have your opinions.
The irony is we are debating about an article that heavily relies on Lustig's work and you don't want to quote him.
It's not a personal preference. Lustig isn't credible. Credibility isn't a fashion or opinion.
Really? If it was not a personal preference, we would not be having this debate, Guardian wouldn't have published an article quoting him heavily, his youtube video wouldn't have gone viral. Every one would have decided he is not credible and he would be found no where. We are having this debate because many consider him credible. It is purely your opinion that he is not credible.2 -
paulgads82 wrote: »Let's assume the rat experiment is applicable, which virtually nobody does in science, but let's assume it does. One study is not enough. What's next? A human study?
This is totally me talking out of my *kitten*, but my assumption is rat studies are always pointed to in these arguments because human studies have never managed to prove the point. I mean, sugar is not a new product. Added sugar is not a new product. It's not like there hasn't been enough time for the powers of added sugar to be tested and trialed. They've done countless studies on the effects (or lack thereof) of artificial sweeteners, so I assume they've done the same and more with sugar. And if any of those studies actually supported any actual causative relationship between sugar and the slew of things it's supposed to cause (other than just what the excess calories cause), I think someone would have posted it by now. At least that's what my little brain assumes
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paulgads82 wrote: »Let's assume the rat experiment is applicable, which virtually nobody does in science, but let's assume it does. One study is not enough. What's next? A human study? I am convinced by rat study and effect on my health by cutting out all added sugar and grains. I don't consider removing added sugars have huge human cost which necessitates endless studies like in case of some drugs where rats are not sufficient and we need human subjects.
We evolved not eating refined sugars, we have seen obesity raise to the point where it has become a public health crisis, we have seen the positive effects on health by cutting out sugar and we will do just fine without added sugar.
And as I said, I have a case study of one, which is myself and I know from personal experience how sugar is appetite stimulant, how it brings out addictive traits in me which has nothing to do with just will power.
More evidence is welcome but not necessary for me.
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pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »stevencloser wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
I hope I've been clear that I think it's more nuanced than just a willpower problem and calling something psychological is in no way a dismissal. If someone tells me they really struggle with sugar I am in no position to say "No you don't get a grip" but can discuss how to categorise it or whether it's the substance itself.
A simple google search will point you to papers. Here is the first link that turned up and I have copied the conclusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/
The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse. According to the evidence in rats, intermittent access to sugar and chow is capable of producing a “dependency”. This was operationally defined by tests for bingeing, withdrawal, craving and cross-sensitization to amphetamine and alcohol. The correspondence to some people with binge eating disorder or bulimia is striking, but whether or not it is a good idea to call this a “food addiction” in people is both a scientific and societal question that has yet to be answered. What this review demonstrates is that rats with intermittent access to food and a sugar solution can show both a constellation of behaviors and parallel brain changes that are characteristic of rats that voluntarily self-administer addictive drugs. In the aggregrate, this is evidence that sugar can be addictive.
Now..please don't tell me that the study was in rats and not applicable to humans.
Why would I not tell you that? The study is literally on rats. This has been discussed already. http://blogs.scientificamerican.com/brainwaves/is-sugar-really-toxic-sifting-through-the-evidence/ Rat study dealt with in this article.
Sure..I did go through the article. I found two places where it mentions rat study.
<snip>
B. Not only do many worrying fructose studies use unrealistic doses of the sugar unaccompanied by glucose, it also turns out that the rodents researchers have studied metabolize fructose in a very different way than people do—far more different than originally anticipated. Studies that have traced fructose's fantastic voyage through the human body suggest that the liver converts as much as 50 percent of fructose into glucose, around 30 percent of fructose into lactate and less than one percent into fats. In contrast, mice and rats turn more than 50 percent of fructose into fats, so experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance.
<snip>
Now..for B. Sure liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat. I have a hard time understanding what is the point the author is trying to make here.
I think your point A has been well covered by other posters. I'd like to address point B.
The paragraph you've quoted here contains two points which go hand in hand in order to reach a conclusion. These are: a human liver would convert as much as 50% of that fructose into glucose; a rat liver would convert more than 50% of it into fat.
We'll add to these facts a third one that you provided:[a human] liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat.
Please bear with me as I piece this together.
As you correctly stated, in a human excess glucose is converted to fat; so then at first glance those aforementioned figures of 50% might appear to be equivalent.
However, please pay close attention to the wording here. It is the excess glucose that is converted into fat, and a human liver may convert as much as 50% of fructose into glucose. Let's use 50 grams of straight fructose, ingested by Alice, as an example to illustrate what I'm trying to say. As much as 25 grams of it could be converted to glucose. How much of that is excess? Of course that would depend on how much glucose Alice's body needs, so it is quite possible that less than 25 grams of the recently-converted glucose is re-converted into fat.
As for a rat or mouse liver, again please pay close attention to the wording. "Mice and rats turn more than 50% of fructose into fats." Returning to our illustration, let's say that Bob the lab rat is fed 50 grams of straight fructose (we're keeping Alice's and Bob's amounts the same only for the sake of simplicity & comparison). Over 25 grams could be converted into fat for poor Bob.
Do you see the subtle yet important difference that could make mouse and rat studies unreliable when extrapolated to humans?
Regarding your point that excess glucose is a "problem in addiction like behavior with sugar causes", here we agree. Excess glucose is a problem. No one says it's OK to consume any form of sugar to the point that your liver begins to turn it to fat; and I would like to see more help available for people who, for whatever reason, engage in addiction-like or compulsive behavior when it comes to food.
Let us consider you argument and take a can of classic coke which is just sugar (so that we don't have fat or any protein or complex carbohydrates coming into equation and a can of coke is something many people consume). Google says it has 39 grams of sugar. Let us say 25% of that get converted to fat which is roughly 10 grams fat per day which is 8 pounds per year and I don't think it is less.
Also, again I restate my my point that many people may not stop at one coke or one cookie or one slice of cake because sugar makes you eat more of it.
Right. But a rat study could potentially show that those 39 grams of sugar (let's say it's all fructose to keep it consistent) convert to as much as 19.5 grams of fat or more because, as the article said, "mice and rats turn more than 50 percent of fructose into fats"; whereas a human " liver converts as much as 50 percent of fructose into glucose", (in the case of the Coke, 19.5 grams or less which then may or may not turn into fat).
This highlights why it can be inaccurate to extrapolate and apply data gathered from rat studies to humans. The author said "experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance." And you said you had a hard time understanding why that would be, and I've attempted to explain.
Again, I agree with your point that many people may not stop after just one because of many reasons. That is unhealthy no matter how you look at it and I'd like to see more help available to people who display compulsive eating habits.
Sure...we applied a correction to compensate for the exaggeration that the article claims and we see it is still a huge impact. So just because he is claiming that differences are exaggerated, it still doesn't mean the impact of sugar on human beings is insignificant. So that argument is not worth much.
Oh OK. Do you know where I can read about that? I'm actually very curious about the validity of rodent studies as applied to humans. I asked a question yesterday about it and didn't get an answer. It would make a huge difference if a correction had been applied to compensate for the differences, and I would have to repent in dust and sack cloth.
We applied the correction you suggested right here for the most reasonable case of a can of coke using the numbers provided by the article and using a liberal estimate that only half of glucose resulting from fructose gets to fats.
Here is a paper where Dr. Lustig answers your question.
http://ac.els-cdn.com/S0002822310019851/1-s2.0-S0002822310019851-main.pdf?_tid=6fc801d8-20a9-11e6-89cf-00000aacb35f&acdnat=1463982457_96671721f8e69b58feaecfc74bea0c9f
Anyways..when claiming exaggeration, Scientific American post refers to a paper which doesn't compare mice and human beings at all. I have no clue where he got the data from. Can you please point me where I can find the information about rats converting 50% of fructose to fat?
And I am getting out of here. It was fun debating with you all.
Please, no Lustig. He's as credible as the guy with the ancient aliens.
Well..you can have your opinions.
The irony is we are debating about an article that heavily relies on Lustig's work and you don't want to quote him.
It's not a personal preference. Lustig isn't credible. Credibility isn't a fashion or opinion.
Really? If it was not a personal preference, we would not be having this debate, Guardian wouldn't have published an article quoting him heavily, his youtube video wouldn't have gone viral. Every one would have decided he is not credible and he would be found no where. We are having this debate because many consider him credible. It is purely your opinion that he is not credible.
The Guardian and YouTube hits aren't reliable measures for scientific credibility. Is this a joke?12 -
pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »stevencloser wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
I hope I've been clear that I think it's more nuanced than just a willpower problem and calling something psychological is in no way a dismissal. If someone tells me they really struggle with sugar I am in no position to say "No you don't get a grip" but can discuss how to categorise it or whether it's the substance itself.
A simple google search will point you to papers. Here is the first link that turned up and I have copied the conclusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/
The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse. According to the evidence in rats, intermittent access to sugar and chow is capable of producing a “dependency”. This was operationally defined by tests for bingeing, withdrawal, craving and cross-sensitization to amphetamine and alcohol. The correspondence to some people with binge eating disorder or bulimia is striking, but whether or not it is a good idea to call this a “food addiction” in people is both a scientific and societal question that has yet to be answered. What this review demonstrates is that rats with intermittent access to food and a sugar solution can show both a constellation of behaviors and parallel brain changes that are characteristic of rats that voluntarily self-administer addictive drugs. In the aggregrate, this is evidence that sugar can be addictive.
Now..please don't tell me that the study was in rats and not applicable to humans.
Why would I not tell you that? The study is literally on rats. This has been discussed already. http://blogs.scientificamerican.com/brainwaves/is-sugar-really-toxic-sifting-through-the-evidence/ Rat study dealt with in this article.
Sure..I did go through the article. I found two places where it mentions rat study.
<snip>
B. Not only do many worrying fructose studies use unrealistic doses of the sugar unaccompanied by glucose, it also turns out that the rodents researchers have studied metabolize fructose in a very different way than people do—far more different than originally anticipated. Studies that have traced fructose's fantastic voyage through the human body suggest that the liver converts as much as 50 percent of fructose into glucose, around 30 percent of fructose into lactate and less than one percent into fats. In contrast, mice and rats turn more than 50 percent of fructose into fats, so experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance.
<snip>
Now..for B. Sure liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat. I have a hard time understanding what is the point the author is trying to make here.
I think your point A has been well covered by other posters. I'd like to address point B.
The paragraph you've quoted here contains two points which go hand in hand in order to reach a conclusion. These are: a human liver would convert as much as 50% of that fructose into glucose; a rat liver would convert more than 50% of it into fat.
We'll add to these facts a third one that you provided:[a human] liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat.
Please bear with me as I piece this together.
As you correctly stated, in a human excess glucose is converted to fat; so then at first glance those aforementioned figures of 50% might appear to be equivalent.
However, please pay close attention to the wording here. It is the excess glucose that is converted into fat, and a human liver may convert as much as 50% of fructose into glucose. Let's use 50 grams of straight fructose, ingested by Alice, as an example to illustrate what I'm trying to say. As much as 25 grams of it could be converted to glucose. How much of that is excess? Of course that would depend on how much glucose Alice's body needs, so it is quite possible that less than 25 grams of the recently-converted glucose is re-converted into fat.
As for a rat or mouse liver, again please pay close attention to the wording. "Mice and rats turn more than 50% of fructose into fats." Returning to our illustration, let's say that Bob the lab rat is fed 50 grams of straight fructose (we're keeping Alice's and Bob's amounts the same only for the sake of simplicity & comparison). Over 25 grams could be converted into fat for poor Bob.
Do you see the subtle yet important difference that could make mouse and rat studies unreliable when extrapolated to humans?
Regarding your point that excess glucose is a "problem in addiction like behavior with sugar causes", here we agree. Excess glucose is a problem. No one says it's OK to consume any form of sugar to the point that your liver begins to turn it to fat; and I would like to see more help available for people who, for whatever reason, engage in addiction-like or compulsive behavior when it comes to food.
Let us consider you argument and take a can of classic coke which is just sugar (so that we don't have fat or any protein or complex carbohydrates coming into equation and a can of coke is something many people consume). Google says it has 39 grams of sugar. Let us say 25% of that get converted to fat which is roughly 10 grams fat per day which is 8 pounds per year and I don't think it is less.
Also, again I restate my my point that many people may not stop at one coke or one cookie or one slice of cake because sugar makes you eat more of it.
Right. But a rat study could potentially show that those 39 grams of sugar (let's say it's all fructose to keep it consistent) convert to as much as 19.5 grams of fat or more because, as the article said, "mice and rats turn more than 50 percent of fructose into fats"; whereas a human " liver converts as much as 50 percent of fructose into glucose", (in the case of the Coke, 19.5 grams or less which then may or may not turn into fat).
This highlights why it can be inaccurate to extrapolate and apply data gathered from rat studies to humans. The author said "experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance." And you said you had a hard time understanding why that would be, and I've attempted to explain.
Again, I agree with your point that many people may not stop after just one because of many reasons. That is unhealthy no matter how you look at it and I'd like to see more help available to people who display compulsive eating habits.
Sure...we applied a correction to compensate for the exaggeration that the article claims and we see it is still a huge impact. So just because he is claiming that differences are exaggerated, it still doesn't mean the impact of sugar on human beings is insignificant. So that argument is not worth much.
Oh OK. Do you know where I can read about that? I'm actually very curious about the validity of rodent studies as applied to humans. I asked a question yesterday about it and didn't get an answer. It would make a huge difference if a correction had been applied to compensate for the differences, and I would have to repent in dust and sack cloth.
We applied the correction you suggested right here for the most reasonable case of a can of coke using the numbers provided by the article and using a liberal estimate that only half of glucose resulting from fructose gets to fats.
Here is a paper where Dr. Lustig answers your question.
http://ac.els-cdn.com/S0002822310019851/1-s2.0-S0002822310019851-main.pdf?_tid=6fc801d8-20a9-11e6-89cf-00000aacb35f&acdnat=1463982457_96671721f8e69b58feaecfc74bea0c9f
Anyways..when claiming exaggeration, Scientific American post refers to a paper which doesn't compare mice and human beings at all. I have no clue where he got the data from. Can you please point me where I can find the information about rats converting 50% of fructose to fat?
And I am getting out of here. It was fun debating with you all.
Please, no Lustig. He's as credible as the guy with the ancient aliens.
Well..you can have your opinions.
The irony is we are debating about an article that heavily relies on Lustig's work and you don't want to quote him.
It's not a personal preference. Lustig isn't credible. Credibility isn't a fashion or opinion.
Really? If it was not a personal preference, we would not be having this debate, Guardian wouldn't have published an article quoting him heavily, his youtube video wouldn't have gone viral. Every one would have decided he is not credible and he would be found no where. We are having this debate because many consider him credible. It is purely your opinion that he is not credible.
So you believe everything you read, then? If it exists it's credible?6 -
pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »stevencloser wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
I hope I've been clear that I think it's more nuanced than just a willpower problem and calling something psychological is in no way a dismissal. If someone tells me they really struggle with sugar I am in no position to say "No you don't get a grip" but can discuss how to categorise it or whether it's the substance itself.
A simple google search will point you to papers. Here is the first link that turned up and I have copied the conclusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/
The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse. According to the evidence in rats, intermittent access to sugar and chow is capable of producing a “dependency”. This was operationally defined by tests for bingeing, withdrawal, craving and cross-sensitization to amphetamine and alcohol. The correspondence to some people with binge eating disorder or bulimia is striking, but whether or not it is a good idea to call this a “food addiction” in people is both a scientific and societal question that has yet to be answered. What this review demonstrates is that rats with intermittent access to food and a sugar solution can show both a constellation of behaviors and parallel brain changes that are characteristic of rats that voluntarily self-administer addictive drugs. In the aggregrate, this is evidence that sugar can be addictive.
Now..please don't tell me that the study was in rats and not applicable to humans.
Why would I not tell you that? The study is literally on rats. This has been discussed already. http://blogs.scientificamerican.com/brainwaves/is-sugar-really-toxic-sifting-through-the-evidence/ Rat study dealt with in this article.
Sure..I did go through the article. I found two places where it mentions rat study.
<snip>
B. Not only do many worrying fructose studies use unrealistic doses of the sugar unaccompanied by glucose, it also turns out that the rodents researchers have studied metabolize fructose in a very different way than people do—far more different than originally anticipated. Studies that have traced fructose's fantastic voyage through the human body suggest that the liver converts as much as 50 percent of fructose into glucose, around 30 percent of fructose into lactate and less than one percent into fats. In contrast, mice and rats turn more than 50 percent of fructose into fats, so experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance.
<snip>
Now..for B. Sure liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat. I have a hard time understanding what is the point the author is trying to make here.
I think your point A has been well covered by other posters. I'd like to address point B.
The paragraph you've quoted here contains two points which go hand in hand in order to reach a conclusion. These are: a human liver would convert as much as 50% of that fructose into glucose; a rat liver would convert more than 50% of it into fat.
We'll add to these facts a third one that you provided:[a human] liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat.
Please bear with me as I piece this together.
As you correctly stated, in a human excess glucose is converted to fat; so then at first glance those aforementioned figures of 50% might appear to be equivalent.
However, please pay close attention to the wording here. It is the excess glucose that is converted into fat, and a human liver may convert as much as 50% of fructose into glucose. Let's use 50 grams of straight fructose, ingested by Alice, as an example to illustrate what I'm trying to say. As much as 25 grams of it could be converted to glucose. How much of that is excess? Of course that would depend on how much glucose Alice's body needs, so it is quite possible that less than 25 grams of the recently-converted glucose is re-converted into fat.
As for a rat or mouse liver, again please pay close attention to the wording. "Mice and rats turn more than 50% of fructose into fats." Returning to our illustration, let's say that Bob the lab rat is fed 50 grams of straight fructose (we're keeping Alice's and Bob's amounts the same only for the sake of simplicity & comparison). Over 25 grams could be converted into fat for poor Bob.
Do you see the subtle yet important difference that could make mouse and rat studies unreliable when extrapolated to humans?
Regarding your point that excess glucose is a "problem in addiction like behavior with sugar causes", here we agree. Excess glucose is a problem. No one says it's OK to consume any form of sugar to the point that your liver begins to turn it to fat; and I would like to see more help available for people who, for whatever reason, engage in addiction-like or compulsive behavior when it comes to food.
Let us consider you argument and take a can of classic coke which is just sugar (so that we don't have fat or any protein or complex carbohydrates coming into equation and a can of coke is something many people consume). Google says it has 39 grams of sugar. Let us say 25% of that get converted to fat which is roughly 10 grams fat per day which is 8 pounds per year and I don't think it is less.
Also, again I restate my my point that many people may not stop at one coke or one cookie or one slice of cake because sugar makes you eat more of it.
Right. But a rat study could potentially show that those 39 grams of sugar (let's say it's all fructose to keep it consistent) convert to as much as 19.5 grams of fat or more because, as the article said, "mice and rats turn more than 50 percent of fructose into fats"; whereas a human " liver converts as much as 50 percent of fructose into glucose", (in the case of the Coke, 19.5 grams or less which then may or may not turn into fat).
This highlights why it can be inaccurate to extrapolate and apply data gathered from rat studies to humans. The author said "experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance." And you said you had a hard time understanding why that would be, and I've attempted to explain.
Again, I agree with your point that many people may not stop after just one because of many reasons. That is unhealthy no matter how you look at it and I'd like to see more help available to people who display compulsive eating habits.
Sure...we applied a correction to compensate for the exaggeration that the article claims and we see it is still a huge impact. So just because he is claiming that differences are exaggerated, it still doesn't mean the impact of sugar on human beings is insignificant. So that argument is not worth much.
Oh OK. Do you know where I can read about that? I'm actually very curious about the validity of rodent studies as applied to humans. I asked a question yesterday about it and didn't get an answer. It would make a huge difference if a correction had been applied to compensate for the differences, and I would have to repent in dust and sack cloth.
We applied the correction you suggested right here for the most reasonable case of a can of coke using the numbers provided by the article and using a liberal estimate that only half of glucose resulting from fructose gets to fats.
Here is a paper where Dr. Lustig answers your question.
http://ac.els-cdn.com/S0002822310019851/1-s2.0-S0002822310019851-main.pdf?_tid=6fc801d8-20a9-11e6-89cf-00000aacb35f&acdnat=1463982457_96671721f8e69b58feaecfc74bea0c9f
Anyways..when claiming exaggeration, Scientific American post refers to a paper which doesn't compare mice and human beings at all. I have no clue where he got the data from. Can you please point me where I can find the information about rats converting 50% of fructose to fat?
And I am getting out of here. It was fun debating with you all.
Please, no Lustig. He's as credible as the guy with the ancient aliens.
Well..you can have your opinions.
The irony is we are debating about an article that heavily relies on Lustig's work and you don't want to quote him.
It's not a personal preference. Lustig isn't credible. Credibility isn't a fashion or opinion.
Really? If it was not a personal preference, we would not be having this debate, Guardian wouldn't have published an article quoting him heavily, his youtube video wouldn't have gone viral. Every one would have decided he is not credible and he would be found no where. We are having this debate because many consider him credible. It is purely your opinion that he is not credible.
Obviously you are entitled to your opinion, and it's awesome you found something that works for you, since so many people don't. But Freelee the Banana Girl is hugely popular and her stuff goes viral all the time. David Wolfe (sp?) shared a post on FB that drilling being done in Russia was dangerous because if they drilled too far in, they would let out gravity, and that went viral. Being popular with the general public does not make you scientifically credible.10 -
paulgads82 wrote: »Let's assume the rat experiment is applicable, which virtually nobody does in science, but let's assume it does. One study is not enough. What's next? A human study?
This is totally me talking out of my *kitten*, but my assumption is rat studies are always pointed to in these arguments because human studies have never managed to prove the point. I mean, sugar is not a new product. Added sugar is not a new product. It's not like there hasn't been enough time for the powers of added sugar to be tested and trialed. They've done countless studies on the effects (or lack thereof) of artificial sweeteners, so I assume they've done the same and more with sugar. And if any of those studies actually supported any actual causative relationship between sugar and the slew of things it's supposed to cause (other than just what the excess calories cause), I think someone would have posted it by now. At least that's what my little brain assumes
A few studies are linked and explained in that scientific American article as well as an explanation of why rats aren't applicable. Through all the debate it could be decided immediately with a simple link to a robust peer reviewed study that has been further validated. There aren't any so far.2 -
paulgads82 wrote: »paulgads82 wrote: »Let's assume the rat experiment is applicable, which virtually nobody does in science, but let's assume it does. One study is not enough. What's next? A human study?
This is totally me talking out of my *kitten*, but my assumption is rat studies are always pointed to in these arguments because human studies have never managed to prove the point. I mean, sugar is not a new product. Added sugar is not a new product. It's not like there hasn't been enough time for the powers of added sugar to be tested and trialed. They've done countless studies on the effects (or lack thereof) of artificial sweeteners, so I assume they've done the same and more with sugar. And if any of those studies actually supported any actual causative relationship between sugar and the slew of things it's supposed to cause (other than just what the excess calories cause), I think someone would have posted it by now. At least that's what my little brain assumes
A few studies are linked and explained in that scientific American article as well as an explanation of why rats aren't applicable. Through all the debate it could be decided immediately with a simple link to a robust peer reviewed study that has been further validated. There aren't any so far.
And it doesn't sound like the poster you're debating with would change her mind anyway. So, debate over, I guess4 -
I will retract my claims upon production of evidence, but it needs to be scientific evidence.4
-
paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »stevencloser wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
I hope I've been clear that I think it's more nuanced than just a willpower problem and calling something psychological is in no way a dismissal. If someone tells me they really struggle with sugar I am in no position to say "No you don't get a grip" but can discuss how to categorise it or whether it's the substance itself.
A simple google search will point you to papers. Here is the first link that turned up and I have copied the conclusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/
The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse. According to the evidence in rats, intermittent access to sugar and chow is capable of producing a “dependency”. This was operationally defined by tests for bingeing, withdrawal, craving and cross-sensitization to amphetamine and alcohol. The correspondence to some people with binge eating disorder or bulimia is striking, but whether or not it is a good idea to call this a “food addiction” in people is both a scientific and societal question that has yet to be answered. What this review demonstrates is that rats with intermittent access to food and a sugar solution can show both a constellation of behaviors and parallel brain changes that are characteristic of rats that voluntarily self-administer addictive drugs. In the aggregrate, this is evidence that sugar can be addictive.
Now..please don't tell me that the study was in rats and not applicable to humans.
Why would I not tell you that? The study is literally on rats. This has been discussed already. http://blogs.scientificamerican.com/brainwaves/is-sugar-really-toxic-sifting-through-the-evidence/ Rat study dealt with in this article.
Sure..I did go through the article. I found two places where it mentions rat study.
<snip>
B. Not only do many worrying fructose studies use unrealistic doses of the sugar unaccompanied by glucose, it also turns out that the rodents researchers have studied metabolize fructose in a very different way than people do—far more different than originally anticipated. Studies that have traced fructose's fantastic voyage through the human body suggest that the liver converts as much as 50 percent of fructose into glucose, around 30 percent of fructose into lactate and less than one percent into fats. In contrast, mice and rats turn more than 50 percent of fructose into fats, so experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance.
<snip>
Now..for B. Sure liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat. I have a hard time understanding what is the point the author is trying to make here.
I think your point A has been well covered by other posters. I'd like to address point B.
The paragraph you've quoted here contains two points which go hand in hand in order to reach a conclusion. These are: a human liver would convert as much as 50% of that fructose into glucose; a rat liver would convert more than 50% of it into fat.
We'll add to these facts a third one that you provided:[a human] liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat.
Please bear with me as I piece this together.
As you correctly stated, in a human excess glucose is converted to fat; so then at first glance those aforementioned figures of 50% might appear to be equivalent.
However, please pay close attention to the wording here. It is the excess glucose that is converted into fat, and a human liver may convert as much as 50% of fructose into glucose. Let's use 50 grams of straight fructose, ingested by Alice, as an example to illustrate what I'm trying to say. As much as 25 grams of it could be converted to glucose. How much of that is excess? Of course that would depend on how much glucose Alice's body needs, so it is quite possible that less than 25 grams of the recently-converted glucose is re-converted into fat.
As for a rat or mouse liver, again please pay close attention to the wording. "Mice and rats turn more than 50% of fructose into fats." Returning to our illustration, let's say that Bob the lab rat is fed 50 grams of straight fructose (we're keeping Alice's and Bob's amounts the same only for the sake of simplicity & comparison). Over 25 grams could be converted into fat for poor Bob.
Do you see the subtle yet important difference that could make mouse and rat studies unreliable when extrapolated to humans?
Regarding your point that excess glucose is a "problem in addiction like behavior with sugar causes", here we agree. Excess glucose is a problem. No one says it's OK to consume any form of sugar to the point that your liver begins to turn it to fat; and I would like to see more help available for people who, for whatever reason, engage in addiction-like or compulsive behavior when it comes to food.
Let us consider you argument and take a can of classic coke which is just sugar (so that we don't have fat or any protein or complex carbohydrates coming into equation and a can of coke is something many people consume). Google says it has 39 grams of sugar. Let us say 25% of that get converted to fat which is roughly 10 grams fat per day which is 8 pounds per year and I don't think it is less.
Also, again I restate my my point that many people may not stop at one coke or one cookie or one slice of cake because sugar makes you eat more of it.
Right. But a rat study could potentially show that those 39 grams of sugar (let's say it's all fructose to keep it consistent) convert to as much as 19.5 grams of fat or more because, as the article said, "mice and rats turn more than 50 percent of fructose into fats"; whereas a human " liver converts as much as 50 percent of fructose into glucose", (in the case of the Coke, 19.5 grams or less which then may or may not turn into fat).
This highlights why it can be inaccurate to extrapolate and apply data gathered from rat studies to humans. The author said "experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance." And you said you had a hard time understanding why that would be, and I've attempted to explain.
Again, I agree with your point that many people may not stop after just one because of many reasons. That is unhealthy no matter how you look at it and I'd like to see more help available to people who display compulsive eating habits.
Sure...we applied a correction to compensate for the exaggeration that the article claims and we see it is still a huge impact. So just because he is claiming that differences are exaggerated, it still doesn't mean the impact of sugar on human beings is insignificant. So that argument is not worth much.
Oh OK. Do you know where I can read about that? I'm actually very curious about the validity of rodent studies as applied to humans. I asked a question yesterday about it and didn't get an answer. It would make a huge difference if a correction had been applied to compensate for the differences, and I would have to repent in dust and sack cloth.
We applied the correction you suggested right here for the most reasonable case of a can of coke using the numbers provided by the article and using a liberal estimate that only half of glucose resulting from fructose gets to fats.
Here is a paper where Dr. Lustig answers your question.
http://ac.els-cdn.com/S0002822310019851/1-s2.0-S0002822310019851-main.pdf?_tid=6fc801d8-20a9-11e6-89cf-00000aacb35f&acdnat=1463982457_96671721f8e69b58feaecfc74bea0c9f
Anyways..when claiming exaggeration, Scientific American post refers to a paper which doesn't compare mice and human beings at all. I have no clue where he got the data from. Can you please point me where I can find the information about rats converting 50% of fructose to fat?
And I am getting out of here. It was fun debating with you all.
Please, no Lustig. He's as credible as the guy with the ancient aliens.
Well..you can have your opinions.
The irony is we are debating about an article that heavily relies on Lustig's work and you don't want to quote him.
It's not a personal preference. Lustig isn't credible. Credibility isn't a fashion or opinion.
Really? If it was not a personal preference, we would not be having this debate, Guardian wouldn't have published an article quoting him heavily, his youtube video wouldn't have gone viral. Every one would have decided he is not credible and he would be found no where. We are having this debate because many consider him credible. It is purely your opinion that he is not credible.
The Guardian and YouTube hits aren't reliable measures for scientific credibility. Is this a joke?
Really...please prove to me that every scientist in the world has labeled Lustig not credible.2 -
pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »stevencloser wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
I hope I've been clear that I think it's more nuanced than just a willpower problem and calling something psychological is in no way a dismissal. If someone tells me they really struggle with sugar I am in no position to say "No you don't get a grip" but can discuss how to categorise it or whether it's the substance itself.
A simple google search will point you to papers. Here is the first link that turned up and I have copied the conclusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/
The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse. According to the evidence in rats, intermittent access to sugar and chow is capable of producing a “dependency”. This was operationally defined by tests for bingeing, withdrawal, craving and cross-sensitization to amphetamine and alcohol. The correspondence to some people with binge eating disorder or bulimia is striking, but whether or not it is a good idea to call this a “food addiction” in people is both a scientific and societal question that has yet to be answered. What this review demonstrates is that rats with intermittent access to food and a sugar solution can show both a constellation of behaviors and parallel brain changes that are characteristic of rats that voluntarily self-administer addictive drugs. In the aggregrate, this is evidence that sugar can be addictive.
Now..please don't tell me that the study was in rats and not applicable to humans.
Why would I not tell you that? The study is literally on rats. This has been discussed already. http://blogs.scientificamerican.com/brainwaves/is-sugar-really-toxic-sifting-through-the-evidence/ Rat study dealt with in this article.
Sure..I did go through the article. I found two places where it mentions rat study.
<snip>
B. Not only do many worrying fructose studies use unrealistic doses of the sugar unaccompanied by glucose, it also turns out that the rodents researchers have studied metabolize fructose in a very different way than people do—far more different than originally anticipated. Studies that have traced fructose's fantastic voyage through the human body suggest that the liver converts as much as 50 percent of fructose into glucose, around 30 percent of fructose into lactate and less than one percent into fats. In contrast, mice and rats turn more than 50 percent of fructose into fats, so experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance.
<snip>
Now..for B. Sure liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat. I have a hard time understanding what is the point the author is trying to make here.
I think your point A has been well covered by other posters. I'd like to address point B.
The paragraph you've quoted here contains two points which go hand in hand in order to reach a conclusion. These are: a human liver would convert as much as 50% of that fructose into glucose; a rat liver would convert more than 50% of it into fat.
We'll add to these facts a third one that you provided:[a human] liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat.
Please bear with me as I piece this together.
As you correctly stated, in a human excess glucose is converted to fat; so then at first glance those aforementioned figures of 50% might appear to be equivalent.
However, please pay close attention to the wording here. It is the excess glucose that is converted into fat, and a human liver may convert as much as 50% of fructose into glucose. Let's use 50 grams of straight fructose, ingested by Alice, as an example to illustrate what I'm trying to say. As much as 25 grams of it could be converted to glucose. How much of that is excess? Of course that would depend on how much glucose Alice's body needs, so it is quite possible that less than 25 grams of the recently-converted glucose is re-converted into fat.
As for a rat or mouse liver, again please pay close attention to the wording. "Mice and rats turn more than 50% of fructose into fats." Returning to our illustration, let's say that Bob the lab rat is fed 50 grams of straight fructose (we're keeping Alice's and Bob's amounts the same only for the sake of simplicity & comparison). Over 25 grams could be converted into fat for poor Bob.
Do you see the subtle yet important difference that could make mouse and rat studies unreliable when extrapolated to humans?
Regarding your point that excess glucose is a "problem in addiction like behavior with sugar causes", here we agree. Excess glucose is a problem. No one says it's OK to consume any form of sugar to the point that your liver begins to turn it to fat; and I would like to see more help available for people who, for whatever reason, engage in addiction-like or compulsive behavior when it comes to food.
Let us consider you argument and take a can of classic coke which is just sugar (so that we don't have fat or any protein or complex carbohydrates coming into equation and a can of coke is something many people consume). Google says it has 39 grams of sugar. Let us say 25% of that get converted to fat which is roughly 10 grams fat per day which is 8 pounds per year and I don't think it is less.
Also, again I restate my my point that many people may not stop at one coke or one cookie or one slice of cake because sugar makes you eat more of it.
Right. But a rat study could potentially show that those 39 grams of sugar (let's say it's all fructose to keep it consistent) convert to as much as 19.5 grams of fat or more because, as the article said, "mice and rats turn more than 50 percent of fructose into fats"; whereas a human " liver converts as much as 50 percent of fructose into glucose", (in the case of the Coke, 19.5 grams or less which then may or may not turn into fat).
This highlights why it can be inaccurate to extrapolate and apply data gathered from rat studies to humans. The author said "experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance." And you said you had a hard time understanding why that would be, and I've attempted to explain.
Again, I agree with your point that many people may not stop after just one because of many reasons. That is unhealthy no matter how you look at it and I'd like to see more help available to people who display compulsive eating habits.
Sure...we applied a correction to compensate for the exaggeration that the article claims and we see it is still a huge impact. So just because he is claiming that differences are exaggerated, it still doesn't mean the impact of sugar on human beings is insignificant. So that argument is not worth much.
Oh OK. Do you know where I can read about that? I'm actually very curious about the validity of rodent studies as applied to humans. I asked a question yesterday about it and didn't get an answer. It would make a huge difference if a correction had been applied to compensate for the differences, and I would have to repent in dust and sack cloth.
We applied the correction you suggested right here for the most reasonable case of a can of coke using the numbers provided by the article and using a liberal estimate that only half of glucose resulting from fructose gets to fats.
Here is a paper where Dr. Lustig answers your question.
http://ac.els-cdn.com/S0002822310019851/1-s2.0-S0002822310019851-main.pdf?_tid=6fc801d8-20a9-11e6-89cf-00000aacb35f&acdnat=1463982457_96671721f8e69b58feaecfc74bea0c9f
Anyways..when claiming exaggeration, Scientific American post refers to a paper which doesn't compare mice and human beings at all. I have no clue where he got the data from. Can you please point me where I can find the information about rats converting 50% of fructose to fat?
And I am getting out of here. It was fun debating with you all.
Please, no Lustig. He's as credible as the guy with the ancient aliens.
Well..you can have your opinions.
The irony is we are debating about an article that heavily relies on Lustig's work and you don't want to quote him.
It's not a personal preference. Lustig isn't credible. Credibility isn't a fashion or opinion.
Really? If it was not a personal preference, we would not be having this debate, Guardian wouldn't have published an article quoting him heavily, his youtube video wouldn't have gone viral. Every one would have decided he is not credible and he would be found no where. We are having this debate because many consider him credible. It is purely your opinion that he is not credible.
Obviously you are entitled to your opinion, and it's awesome you found something that works for you, since so many people don't. But Freelee the Banana Girl is hugely popular and her stuff goes viral all the time. David Wolfe (sp?) shared a post on FB that drilling being done in Russia was dangerous because if they drilled too far in, they would let out gravity, and that went viral. Being popular with the general public does not make you scientifically credible.
Sure..please prove to me that entire scientific community has discredited Lustig.2 -
paulgads82 wrote: »paulgads82 wrote: »Let's assume the rat experiment is applicable, which virtually nobody does in science, but let's assume it does. One study is not enough. What's next? A human study?
This is totally me talking out of my *kitten*, but my assumption is rat studies are always pointed to in these arguments because human studies have never managed to prove the point. I mean, sugar is not a new product. Added sugar is not a new product. It's not like there hasn't been enough time for the powers of added sugar to be tested and trialed. They've done countless studies on the effects (or lack thereof) of artificial sweeteners, so I assume they've done the same and more with sugar. And if any of those studies actually supported any actual causative relationship between sugar and the slew of things it's supposed to cause (other than just what the excess calories cause), I think someone would have posted it by now. At least that's what my little brain assumes
A few studies are linked and explained in that scientific American article as well as an explanation of why rats aren't applicable. Through all the debate it could be decided immediately with a simple link to a robust peer reviewed study that has been further validated. There aren't any so far.
And it doesn't sound like the poster you're debating with would change her mind anyway. So, debate over, I guess
Exactly...this debate is over. I am not going to change my mind (at least with evidence provided here and the kind of absolute statements made as if they have experienced every thing about sugar and so know everything about sugar), neither the people whom I am debating with.2 -
Sorry but not going to get drawn into fallacious arguments.2
-
pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »stevencloser wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
I hope I've been clear that I think it's more nuanced than just a willpower problem and calling something psychological is in no way a dismissal. If someone tells me they really struggle with sugar I am in no position to say "No you don't get a grip" but can discuss how to categorise it or whether it's the substance itself.
A simple google search will point you to papers. Here is the first link that turned up and I have copied the conclusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/
The reviewed evidence supports the theory that, in some circumstances, intermittent access to sugar can lead to behavior and neurochemical changes that resemble the effects of a substance of abuse. According to the evidence in rats, intermittent access to sugar and chow is capable of producing a “dependency”. This was operationally defined by tests for bingeing, withdrawal, craving and cross-sensitization to amphetamine and alcohol. The correspondence to some people with binge eating disorder or bulimia is striking, but whether or not it is a good idea to call this a “food addiction” in people is both a scientific and societal question that has yet to be answered. What this review demonstrates is that rats with intermittent access to food and a sugar solution can show both a constellation of behaviors and parallel brain changes that are characteristic of rats that voluntarily self-administer addictive drugs. In the aggregrate, this is evidence that sugar can be addictive.
Now..please don't tell me that the study was in rats and not applicable to humans.
Why would I not tell you that? The study is literally on rats. This has been discussed already. http://blogs.scientificamerican.com/brainwaves/is-sugar-really-toxic-sifting-through-the-evidence/ Rat study dealt with in this article.
Sure..I did go through the article. I found two places where it mentions rat study.
<snip>
B. Not only do many worrying fructose studies use unrealistic doses of the sugar unaccompanied by glucose, it also turns out that the rodents researchers have studied metabolize fructose in a very different way than people do—far more different than originally anticipated. Studies that have traced fructose's fantastic voyage through the human body suggest that the liver converts as much as 50 percent of fructose into glucose, around 30 percent of fructose into lactate and less than one percent into fats. In contrast, mice and rats turn more than 50 percent of fructose into fats, so experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance.
<snip>
Now..for B. Sure liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat. I have a hard time understanding what is the point the author is trying to make here.
I think your point A has been well covered by other posters. I'd like to address point B.
The paragraph you've quoted here contains two points which go hand in hand in order to reach a conclusion. These are: a human liver would convert as much as 50% of that fructose into glucose; a rat liver would convert more than 50% of it into fat.
We'll add to these facts a third one that you provided:[a human] liver converts 50% of fructose into glucose..if that glucose is in excess of what body needs (which is the problem in addiction like behavior with sugar causes), it gets converted to fat.
Please bear with me as I piece this together.
As you correctly stated, in a human excess glucose is converted to fat; so then at first glance those aforementioned figures of 50% might appear to be equivalent.
However, please pay close attention to the wording here. It is the excess glucose that is converted into fat, and a human liver may convert as much as 50% of fructose into glucose. Let's use 50 grams of straight fructose, ingested by Alice, as an example to illustrate what I'm trying to say. As much as 25 grams of it could be converted to glucose. How much of that is excess? Of course that would depend on how much glucose Alice's body needs, so it is quite possible that less than 25 grams of the recently-converted glucose is re-converted into fat.
As for a rat or mouse liver, again please pay close attention to the wording. "Mice and rats turn more than 50% of fructose into fats." Returning to our illustration, let's say that Bob the lab rat is fed 50 grams of straight fructose (we're keeping Alice's and Bob's amounts the same only for the sake of simplicity & comparison). Over 25 grams could be converted into fat for poor Bob.
Do you see the subtle yet important difference that could make mouse and rat studies unreliable when extrapolated to humans?
Regarding your point that excess glucose is a "problem in addiction like behavior with sugar causes", here we agree. Excess glucose is a problem. No one says it's OK to consume any form of sugar to the point that your liver begins to turn it to fat; and I would like to see more help available for people who, for whatever reason, engage in addiction-like or compulsive behavior when it comes to food.
Let us consider you argument and take a can of classic coke which is just sugar (so that we don't have fat or any protein or complex carbohydrates coming into equation and a can of coke is something many people consume). Google says it has 39 grams of sugar. Let us say 25% of that get converted to fat which is roughly 10 grams fat per day which is 8 pounds per year and I don't think it is less.
Also, again I restate my my point that many people may not stop at one coke or one cookie or one slice of cake because sugar makes you eat more of it.
Right. But a rat study could potentially show that those 39 grams of sugar (let's say it's all fructose to keep it consistent) convert to as much as 19.5 grams of fat or more because, as the article said, "mice and rats turn more than 50 percent of fructose into fats"; whereas a human " liver converts as much as 50 percent of fructose into glucose", (in the case of the Coke, 19.5 grams or less which then may or may not turn into fat).
This highlights why it can be inaccurate to extrapolate and apply data gathered from rat studies to humans. The author said "experiments with these animals would exaggerate the significance of fructose's proposed detriments for humans, especially clogged arteries, fatty livers and insulin resistance." And you said you had a hard time understanding why that would be, and I've attempted to explain.
Again, I agree with your point that many people may not stop after just one because of many reasons. That is unhealthy no matter how you look at it and I'd like to see more help available to people who display compulsive eating habits.
Sure...we applied a correction to compensate for the exaggeration that the article claims and we see it is still a huge impact. So just because he is claiming that differences are exaggerated, it still doesn't mean the impact of sugar on human beings is insignificant. So that argument is not worth much.
Oh OK. Do you know where I can read about that? I'm actually very curious about the validity of rodent studies as applied to humans. I asked a question yesterday about it and didn't get an answer. It would make a huge difference if a correction had been applied to compensate for the differences, and I would have to repent in dust and sack cloth.
We applied the correction you suggested right here for the most reasonable case of a can of coke using the numbers provided by the article and using a liberal estimate that only half of glucose resulting from fructose gets to fats.
Here is a paper where Dr. Lustig answers your question.
http://ac.els-cdn.com/S0002822310019851/1-s2.0-S0002822310019851-main.pdf?_tid=6fc801d8-20a9-11e6-89cf-00000aacb35f&acdnat=1463982457_96671721f8e69b58feaecfc74bea0c9f
Anyways..when claiming exaggeration, Scientific American post refers to a paper which doesn't compare mice and human beings at all. I have no clue where he got the data from. Can you please point me where I can find the information about rats converting 50% of fructose to fat?
And I am getting out of here. It was fun debating with you all.
Please, no Lustig. He's as credible as the guy with the ancient aliens.
Well..you can have your opinions.
The irony is we are debating about an article that heavily relies on Lustig's work and you don't want to quote him.
It's not a personal preference. Lustig isn't credible. Credibility isn't a fashion or opinion.
Really? If it was not a personal preference, we would not be having this debate, Guardian wouldn't have published an article quoting him heavily, his youtube video wouldn't have gone viral. Every one would have decided he is not credible and he would be found no where. We are having this debate because many consider him credible. It is purely your opinion that he is not credible.
Being viral on YouTube as a measure of credibility!!!!! That's a good one!!!!!!
Tell me another!!!
I guess you're abandoning keto in favor of Freelee's recommendation to eat scores of bananas a day??
I mean, I'm pretty sure she's more viral, thus more credible than Lustig.9 -
1
-
pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »pcoslady83 wrote: »paulgads82 wrote: »
It's a scientific debate, semantics are important. I think we are all just geeks who like debating
But its also important in the context of the idea of a sugar conspiracy, or whatever. Are corporate interests feeding us an addictive substance or is sugar just really tasty and some of us develop unhealthy relationships with it? Obviously i support the latter explanation.
I believe refined sugar is addictive to many people and at the minimum an appetite stimulant which interferes with normal brain functionality. So I think corporations are using these attributes of sugar to increase profits.
Aaaaannnnnndddddddd...I don't like debating at all. I used to though, but when I started understanding that different people experience different realities when faced with an objectively same situation, debating became less interesting and learning about different experiences and perspective became more interesting.
Experiences do not negate reality. If I start seeing unicorns, the unicorns are not there. It's me. The fact that I saw unicorns is real, the existence of unicorns is not. If someone believes they are physically addicted to sugar the only way to determine if this is true is through science.
Sure science will determine that...eventually. Till then, it is good to have an open mind.
I do. It's open to evidence.
Then..let us just wait and respect people's experiences rather than dismissing them as willpower problem.
So once again someone tries to claim that she is not responsible for gaining weight, unlike the rest if us.
Sorry, your weight issues are NOT different from those of others. If it's willpower for us, it's willpower for you.7 -
pcoslady83 wrote: »paulgads82 wrote: »paulgads82 wrote: »Let's assume the rat experiment is applicable, which virtually nobody does in science, but let's assume it does. One study is not enough. What's next? A human study?
This is totally me talking out of my *kitten*, but my assumption is rat studies are always pointed to in these arguments because human studies have never managed to prove the point. I mean, sugar is not a new product. Added sugar is not a new product. It's not like there hasn't been enough time for the powers of added sugar to be tested and trialed. They've done countless studies on the effects (or lack thereof) of artificial sweeteners, so I assume they've done the same and more with sugar. And if any of those studies actually supported any actual causative relationship between sugar and the slew of things it's supposed to cause (other than just what the excess calories cause), I think someone would have posted it by now. At least that's what my little brain assumes
A few studies are linked and explained in that scientific American article as well as an explanation of why rats aren't applicable. Through all the debate it could be decided immediately with a simple link to a robust peer reviewed study that has been further validated. There aren't any so far.
And it doesn't sound like the poster you're debating with would change her mind anyway. So, debate over, I guess
Exactly...this debate is over. I am not going to change my mind, neither the people whom I am debating with.
I don't mean to be rude but I've given enough opportunities for people to provide scientific evidence. I've given some, you've provided a belief. That's not how science works and its clear this is not going to be scientific debate but one based on belief and a misunderstanding of the scientific process.10 -
paulgads82 wrote: »Let's assume the rat experiment is applicable, which virtually nobody does in science, but let's assume it does. One study is not enough. What's next? A human study?
This is totally me talking out of my *kitten*, but my assumption is rat studies are always pointed to in these arguments because human studies have never managed to prove the point. I mean, sugar is not a new product. Added sugar is not a new product. It's not like there hasn't been enough time for the powers of added sugar to be tested and trialed. They've done countless studies on the effects (or lack thereof) of artificial sweeteners, so I assume they've done the same and more with sugar. And if any of those studies actually supported any actual causative relationship between sugar and the slew of things it's supposed to cause (other than just what the excess calories cause), I think someone would have posted it by now. At least that's what my little brain assumes
This article from earlier this year about sums it up I think.
Sugar consumption, metabolic disease and obesity: The state of the controversy.
The impact of sugar consumption on health continues to be a controversial topic. The objective of this review is to discuss the evidence and lack of evidence that allows the controversy to continue, and why resolution of the controversy is important.
There are plausible mechanisms and research evidence that supports the suggestion that consumption of excess sugar promotes the development of cardiovascular disease (CVD) and type 2 diabetes (T2DM) both directly and indirectly. The direct pathway involves the unregulated hepatic uptake and metabolism of fructose, leading to liver lipid accumulation, dyslipidemia, decreased insulin sensitivity and increased uric acid levels. The epidemiological data suggest that these direct effects of fructose are pertinent to the consumption of the fructose-containing sugars, sucrose and high fructose corn syrup (HFCS), which are the predominant added sugars.
Consumption of added sugar is associated with development and/or prevalence of fatty liver, dyslipidemia, insulin resistance, hyperuricemia, CVD and T2DM, often independent of body weight gain or total energy intake. There are diet intervention studies in which human subjects exhibited increased circulating lipids and decreased insulin sensitivity when consuming high sugar compared with control diets. Most recently, our group has reported that supplementing the ad libitum diets of young adults with beverages containing 0%, 10%, 17.5% or 25% of daily energy requirement (Ereq) as HFCS increased lipid/lipoprotein risk factors for CVD and uric acid in a dose-response manner.
However, un-confounded studies conducted in healthy humans under a controlled, energy-balanced diet protocol that enables determination of the effects of sugar with diets that do not allow for body weight gain are lacking. Furthermore, recent reports conclude that there are no adverse effects of consuming beverages containing up to 30% Ereq sucrose or HFCS, and the conclusions from several meta-analyses suggest that fructose has no specific adverse effects relative to any other carbohydrate.
Consumption of excess sugar may also promote the development of CVD and T2DM indirectly by causing increased body weight and fat gain, but this is also a topic of controversy. Mechanistically, it is plausible that fructose consumption causes increased energy intake and reduced energy expenditure due to its failure to stimulate leptin production.
Functional magnetic resonance imaging (fMRI) of the brain demonstrates that the brain responds differently to fructose or fructose-containing sugars compared with glucose or aspartame. Some epidemiological studies show that sugar consumption is associated with body weight gain, and there are intervention studies in which consumption of ad libitum high-sugar diets promoted increased body weight gain compared with consumption of ad libitum low- sugar diets.
However, there are no studies in which energy intake and weight gain were compared in subjects consuming high or low sugar, blinded, ad libitum diets formulated to ensure both groups consumed a comparable macronutrient distribution and the same amounts of fiber. There is also little data to determine whether the form in which added sugar is consumed, as beverage or as solid food, affects its potential to promote weight gain.
It will be very challenging to obtain the funding to conduct the clinical diet studies needed to address these evidence gaps, especially at the levels of added sugar that are commonly consumed. Yet, filling these evidence gaps may be necessary for supporting the policy changes that will help to turn the food environment into one that does not promote the development of obesity and metabolic disease.
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