New Discovery: Protein shuts down Fat burning
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TallGent66
Posts: 84 Member
The Atlantic: A Potential Hidden Factor in Why People Have So Much Trouble Losing Weight
A new study in mice points to how cell biology, not willpower, might be the root of yo-yo dieting.
By Amanda Mull
"The American conventional wisdom about weight loss is simple: A calorie deficit is all that’s required to drop excess pounds, and moderating future calorie consumption is all that’s required to maintain it. To the idea’s adherents, the infinite complexity of human biology acts as one big nutritional piggy bank. Anyone who gains too much weight or loses weight and gains it back has simply failed to balance the caloric checkbook, which can be corrected by forswearing fatty food or carbs."
"Endocrinologists have known for decades that the science of weight is far more complicated than calorie deficits and energy expenditures...."
"...In a new study published today, Schmidt and her team have unlocked a molecular mechanism controlling weight gain and loss in mice: a protein that shuts down the animals’ ability to burn fat in times of bodily stress, including when dieting or overeating. This discovery might hold the key to understanding why it’s so hard for humans to lose weight, and even harder to keep it off."
https://www.theatlantic.com/health/archive/2019/07/weight-loss-rage-proteins/594073/
A new study in mice points to how cell biology, not willpower, might be the root of yo-yo dieting.
By Amanda Mull
"The American conventional wisdom about weight loss is simple: A calorie deficit is all that’s required to drop excess pounds, and moderating future calorie consumption is all that’s required to maintain it. To the idea’s adherents, the infinite complexity of human biology acts as one big nutritional piggy bank. Anyone who gains too much weight or loses weight and gains it back has simply failed to balance the caloric checkbook, which can be corrected by forswearing fatty food or carbs."
"Endocrinologists have known for decades that the science of weight is far more complicated than calorie deficits and energy expenditures...."
"...In a new study published today, Schmidt and her team have unlocked a molecular mechanism controlling weight gain and loss in mice: a protein that shuts down the animals’ ability to burn fat in times of bodily stress, including when dieting or overeating. This discovery might hold the key to understanding why it’s so hard for humans to lose weight, and even harder to keep it off."
https://www.theatlantic.com/health/archive/2019/07/weight-loss-rage-proteins/594073/
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Replies
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TallGent66 wrote: »The Atlantic: A Potential Hidden Factor in Why People Have So Much Trouble Losing Weight
A new study in mice points to how cell biology, not willpower, might be the root of yo-yo dieting.
By Amanda Mull
"The American conventional wisdom about weight loss is simple: A calorie deficit is all that’s required to drop excess pounds, and moderating future calorie consumption is all that’s required to maintain it. To the idea’s adherents, the infinite complexity of human biology acts as one big nutritional piggy bank. Anyone who gains too much weight or loses weight and gains it back has simply failed to balance the caloric checkbook, which can be corrected by forswearing fatty food or carbs."
"Endocrinologists have known for decades that the science of weight is far more complicated than calorie deficits and energy expenditures...."
"...In a new study published today, Schmidt and her team have unlocked a molecular mechanism controlling weight gain and loss in mice: a protein that shuts down the animals’ ability to burn fat in times of bodily stress, including when dieting or overeating. This discovery might hold the key to understanding why it’s so hard for humans to lose weight, and even harder to keep it off."
https://www.theatlantic.com/health/archive/2019/07/weight-loss-rage-proteins/594073/
Old news, but thanks for posting. We know whole food high carb vegan or keto, as long as they are stuck to, tend work.27 -
Thank you @TallGent66 for sharing. I enjoyed reading the article.9
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From the article:Humans and other mammals have a protein on the surface of fat cells
A protein on the surface of fat cells isn't protein in the diet.
Just to be clear, because the title of your thread is misleading.
The more fat cells the more effect this will have, obviously.26 -
cmriverside wrote: »From the article:Humans and other mammals have a protein on the surface of fat cells
A protein on the surface of fat cells isn't protein in the diet.
Just to be clear, because the title of your thread is misleading.
The more fat cells the more effect this will have, obviously.
Just wanted to second the bolded. The study is not about eating protein, it's about a protein found in the body of mice.
The article unfortunately reads like the typical media reporting of scientific research, lots of flashbang and tricky wording. I clicked through to the actual paper and took a glance, but it was really dense with measurements and terminology and my brain just wasn't up to picking through it right now23 -
In general, most of the successful people here tend to eat higher than normal recommended intakes of protein during their weight loss. I'm not saying that it's a requirement, I'm just saying that it is certainly not hindering their weight loss. I'll take that evidence over hypothetical studies in mice. The idea that protein would prevent weight loss would go against pretty much all observational weight loss study throughout history.
I also take issue with the idea in this article that "its so hard for humans to lose weight" . I am sympathetic to those who struggle with it, but a big reason why people struggle I feel is because they have been told that it's hard and they need to do whatever new oveecomplicated method a blog has given them. That makes it uncessarily complicated and harder than it needs to be. Weight loss does not need to be so complicated and "so hard".
Consistently eat at a reasonable calorie deficit, and you will lose weight. Everyone else is just trying to sell you something, or fill blog pages.24 -
In general, most of the successful people here tend to eat higher than normal recommended intakes of protein during their weight loss. I'm not saying that it's a requirement, I'm just saying that it is certainly not hindering their weight loss. I'll take that evidence over hypothetical studies in mice. The idea that protein would prevent weight loss would go against pretty much all observational weight loss study throughout history.
I also take issue with the idea in this article that "its so hard for humans to lose weight" . I am sympathetic to those who struggle with it, but a big reason why people struggle I feel is because they have been told that it's hard and they need to do whatever new oveecomplicated method a blog has given them. That makes it uncessarily complicated and harder than it needs to be. Weight loss does not need to be so complicated and "so hard".
Consistently eat at a reasonable calorie deficit, and you will lose weight. Everyone else is just trying to sell you something, or fill blog pages.
It's not referring to dietary protein or overall intake. It's referring to a protein called RAGE (no seriously that's what the abbreviation is 😂) that supposedly influences cellular fat loss in mice.12 -
New_Heavens_Earth wrote: »In general, most of the successful people here tend to eat higher than normal recommended intakes of protein during their weight loss. I'm not saying that it's a requirement, I'm just saying that it is certainly not hindering their weight loss. I'll take that evidence over hypothetical studies in mice. The idea that protein would prevent weight loss would go against pretty much all observational weight loss study throughout history.
I also take issue with the idea in this article that "its so hard for humans to lose weight" . I am sympathetic to those who struggle with it, but a big reason why people struggle I feel is because they have been told that it's hard and they need to do whatever new oveecomplicated method a blog has given them. That makes it uncessarily complicated and harder than it needs to be. Weight loss does not need to be so complicated and "so hard".
Consistently eat at a reasonable calorie deficit, and you will lose weight. Everyone else is just trying to sell you something, or fill blog pages.
It's not referring to dietary protein or overall intake. It's referring to a protein called RAGE (no seriously that's what the abbreviation is 😂) that supposedly influences cellular fat loss in mice.
I don't have an issue with the study. My issue is with the post and the article which is massively misleading that study.15 -
New_Heavens_Earth wrote: »In general, most of the successful people here tend to eat higher than normal recommended intakes of protein during their weight loss. I'm not saying that it's a requirement, I'm just saying that it is certainly not hindering their weight loss. I'll take that evidence over hypothetical studies in mice. The idea that protein would prevent weight loss would go against pretty much all observational weight loss study throughout history.
I also take issue with the idea in this article that "its so hard for humans to lose weight" . I am sympathetic to those who struggle with it, but a big reason why people struggle I feel is because they have been told that it's hard and they need to do whatever new oveecomplicated method a blog has given them. That makes it uncessarily complicated and harder than it needs to be. Weight loss does not need to be so complicated and "so hard".
Consistently eat at a reasonable calorie deficit, and you will lose weight. Everyone else is just trying to sell you something, or fill blog pages.
It's not referring to dietary protein or overall intake. It's referring to a protein called RAGE (no seriously that's what the abbreviation is 😂) that supposedly influences cellular fat loss in mice.
I don't have an issue with the study. My issue is with the post and the article which is massively misleading that study.
That it is.8 -
The study is much closer to saying that stress causes you to retain fat than saying anything about dietary protein being a hindrance for weight loss.
Also, it isn't "so hard for humans to lose weight". Humans have been losing weight, willingly or unwillingly, for tens of thousands of years. A 500 calorie daily deficit causes a 1 lb per week weight loss, always has, always will. Losing weight is easy if you maintain the correct calorie deficit. The hard part is exerting the self discipline to achieve the calorie deficit if you have access to food and want some.17 -
Losing weight is actually pretty easy, sustaining the weight loss to goal or especially keeping the weight off is what humans seem to be bad at in the current environment. Not sure how the article addresses that, but I suppose I should read it.8
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I guess reading comprehension is now rare.8
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I lost plenty of weight by counting calories. I've kept most of it off for years by calories.
If eating protein keeps you fat for life, calorie counting is like kriptonite for protein, because a ton of people control their weight with calories.5 -
The title of this post in click bait and not representative of the info in the study. It is really inaccurate.11
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Did OP even read the article? Just FYI...dietary protein is not the same as gene manipulation13
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Keto_Vampire wrote: »Did OP even read the article?
I can't tell if it was intentional clickbait or if they just misunderstood the entire article completely.4 -
In fairness, we all took it to mean dietary protein. OP simply said "Protein"... That's on us as much as it is on OP, no?9
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Sure, but I think that in a nutrition and fitness forum, leaving "protein" ambiguous tends to lead people into assuming you mean dietary.4
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nevermind...5
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Would Cellular Protein have been a better title?
Most seem to have skipped this paragraph:
"Endocrinologists have known for decades that the science of weight is far more complicated than calorie deficits and energy expenditures...."
Not negating that many, or most, can lose weight on a caloric deficit.
It would be interesting if they reviewed all of the Biggest Losers. A tough subgroup. Did they go back to their old ways, stop exercising? One of the Juice Guys lost a ton of weight, became famous, had life changes, and put most of the weight back on.
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