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FDA to intervene in wild CBD claims
NorthCascades
Posts: 10,968 Member
in Debate Club
If you want to watch a hippie's head explode, tell them that if CBD really cured everything, "big pharma" would have never let "them" legalize it. 😆
The company Curaleaf claims that it has developed products that can treat a slew of the most formidable conditions found in humans, including cancer, Alzheimer’s, Parkinson’s, depression, opioid withdrawal, chronic pain, anxiety, post-traumatic stress disorder (PTSD), and attention deficit/hyperactivity disorder (ADHD). It also has products said to treat anxiety, pain, and diabetes in cats and dogs. (The product comes in bacon and salmon flavors.) And just one ingredient in all of its products is responsible for these remarkable medical breakthroughs: the cannabis-derived compound cannabidiol (CBD).
Sadly, those claims are not backed by evidence.
This week the Food and Drug Administration announced that it sent Curaleaf a warning letter for illegally selling unapproved drugs and making unsubstantiated treatment claims.
https://arstechnica.com/science/2019/07/a-cure-for-cancer-alzheimers-depression-fda-smacks-down-wild-cbd-claims/
The company Curaleaf claims that it has developed products that can treat a slew of the most formidable conditions found in humans, including cancer, Alzheimer’s, Parkinson’s, depression, opioid withdrawal, chronic pain, anxiety, post-traumatic stress disorder (PTSD), and attention deficit/hyperactivity disorder (ADHD). It also has products said to treat anxiety, pain, and diabetes in cats and dogs. (The product comes in bacon and salmon flavors.) And just one ingredient in all of its products is responsible for these remarkable medical breakthroughs: the cannabis-derived compound cannabidiol (CBD).
Sadly, those claims are not backed by evidence.
This week the Food and Drug Administration announced that it sent Curaleaf a warning letter for illegally selling unapproved drugs and making unsubstantiated treatment claims.
https://arstechnica.com/science/2019/07/a-cure-for-cancer-alzheimers-depression-fda-smacks-down-wild-cbd-claims/
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The amount of eye rolling I do on a near daily basis about CBD, I swear....well you know, you're only 3ish hours north of me.3
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I'm not sure how objective I can be about this, but I'mma try...
To what extent do semantics matter? For example... may treat vs can treat vs does treat?2 -
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Can CBD in real terms do anything0
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I feel like CBD is the new coconut oil. A few years from now we'll be reading about how bad it is for us and how much it doesn't actually cure. Or maybe they'll just come out with CBD coconut oil as the super health supplement of 2020.8
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can it cure thing? no
could it treat? possibly
does it need more intensive and in depth studies? yes, if people want to have it as an alternative to medication.
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I note that CBD like all supplements is labeled a supplement as it cannot produce objective evidence to support its claims.
It simply does not hold a level of risk where it requires a prescription.6 -
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A few people in my yoga class were talking last month about how they were giving their dogs CBD laced treats to help keep them calm during the 4th of July fireworks. I've been afraid to ask how it turned out. Hopefully okay.1
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Crafty_camper123 wrote: »I feel like CBD is the new coconut oil. A few years from now we'll be reading about how bad it is for us and how much it doesn't actually cure. Or maybe they'll just come out with CBD coconut oil as the super health supplement of 2020.
I totally agree with you.2 -
I have never bought/probably will never buy. But I have seen people suffering in the last few days of life and heard the Dr. say, I only wish we could get them some marijuana to help with the pain. I will be the first person in line to get cbd if that happens again, just in case it might possibly help.11
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And might get some snake oil while I’m at it, if I can find it.3
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In some very specific cases, yes. For the most part, however - I don't know of many studies that have proven it to be helpful for much of anything.richardsullivanu wrote: »Can CBD in real terms do anything
There is an FDA approved drug called Epidiolex that is used to treat two different rare forms of epilepsy. From what I understand, the primary active ingredient is CBD. There have also been other instances of people using or trying to use CBD to treat epilepsy. There have been a number of stories written about about a girl who was then 5 years old whose parents successfully used a strain of marijuana that was very high in CBD and extremely low in THC to help control her seizures. There's a link from CNN here. She, mind you, wasn't the first child who had successfully been treated this way.
I wouldn't be shocked if it's found that there are other things that can be successfully treated with CBD, but that isn't really the market that various stores are targeting right now.7 -
In some very specific cases, yes. For the most part, however - I don't know of many studies that have proven it to be helpful for much of anything.richardsullivanu wrote: »Can CBD in real terms do anything
There is an FDA approved drug called Epidiolex that is used to treat two different rare forms of epilepsy. From what I understand, the primary active ingredient is CBD. There have also been other instances of people using or trying to use CBD to treat epilepsy. There have been a number of stories written about about a girl who was then 5 years old whose parents successfully used a strain of marijuana that was very high in CBD and extremely low in THC to help control her seizures. There's a link from CNN here. She, mind you, wasn't the first child who had successfully been treated this way.
I wouldn't be shocked if it's found that there are other things that can be successfully treated with CBD, but that isn't really the market that various stores are targeting right now.
And that's kind of where I was going with my earlier comment.
Does it necessarily help/treat/cure? No.
Can it help/treat? In some cases, for some people, there is evidence *suggesting* that it *can*.
Given that there doesn't seem to be any *significant* risk, the fact that there is suggestive evidence is meaningful. But like you said... these scenarios and these people and these markets aren't really what OP's post/company is targeting.0 -
https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-questions-and-answers
It's a bunch of snake oil & I foresee a bunch of market hype/BS; sell as much as possible as quick as possible because I am sure the FDA will intervene soon enough (might take a few years & possibly some more legislation).3 -
CBD oil helps in my hubby's case. As a disabled vet, he has a screwed up wrist, screwed up knees and essentially his entire cervical spine (except the first one at the base of the skull) has been fused in multiple surgeries, also 2 to fix previous fusions. He has permanent nerve damage and has not know a pain free day in about 20 years. He has to go to the VA hospital which does not believe in pain medications and tells you to go to physical therapy (doesn't work for what hubby has going on). All his injuries stem from his stint in the Navy during Desert Storm and a few other operations that were not always on the official books. He is also dealing with Gulf War Syndrome which encompasses fibromyalgia, chronic fatigue, memory issues, sleep issues, general neurological issues, digestive issues and more. He has ALL of these things!
CBD oil does not cure anything but if you have a good quality product, it will dampen down the pain so that you can function with daily living. He is still in pain but he is not curled up on the couch unable to move and function. So in our case, yes, CBD oil works! It is important to find a quality product though ...20 -
A few people in my yoga class were talking last month about how they were giving their dogs CBD laced treats to help keep them calm during the 4th of July fireworks. I've been afraid to ask how it turned out. Hopefully okay.
I don't think the stuff is harmful in and of itself. I think the real danger is that people can think they're curing themselves and not seek actual medical treatment for something dangerous.
My vet gave me gabapentin for the cats for the 4th of July. I don't know why I thought the younger one wouldn't need it, but I found him hiding in the closet.2 -
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NorthCascades wrote: »If you want to watch a hippie's head explode, tell them that if CBD really cured everything, "big pharma" would have never let "them" legalize it. 😆
The company Curaleaf claims that it has developed products that can treat a slew of the most formidable conditions found in humans, including cancer, Alzheimer’s, Parkinson’s, depression, opioid withdrawal, chronic pain, anxiety, post-traumatic stress disorder (PTSD), and attention deficit/hyperactivity disorder (ADHD). It also has products said to treat anxiety, pain, and diabetes in cats and dogs. (The product comes in bacon and salmon flavors.) And just one ingredient in all of its products is responsible for these remarkable medical breakthroughs: the cannabis-derived compound cannabidiol (CBD).
Sadly, those claims are not backed by evidence.
This week the Food and Drug Administration announced that it sent Curaleaf a warning letter for illegally selling unapproved drugs and making unsubstantiated treatment claims.
https://arstechnica.com/science/2019/07/a-cure-for-cancer-alzheimers-depression-fda-smacks-down-wild-cbd-claims/
@NorthCascades here are a few things that your "big pharma" knows about CBD from 45 years of research.
Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
https://ncbi.nlm.nih.gov/pmc/articles/PMC3232190/
"However, in this study we demonstrate that during intestinal inflammation, CBD is able to control the inflammatory scenario and the subsequent intestinal apoptosis through the restoration of the altered glia-immune homeostasis. CBD is therefore regarded as a promising therapeutic agent that modulates the neuro-immune axis, which can be recognised as a new target in the treatment of inflammatory bowel disorders."
An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
https://ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
After 45 years of research on CBD usage some of the disease states are name with CBD results on said disease states near the end of this paper.
Cannabidiol in Anxiety and Sleep: A Large Case Series
https://ncbi.nlm.nih.gov/pmc/articles/PMC6326553/
CONCLUSION
Formal studies on efficacy and dose finding are much needed. Some urgency exists, given the explosion of lay interest in this topic and the rush to market these compounds. Current understanding of the physiology and neurologic pathways points to a benefit with anxiety-related issues. The results of our clinical report support the existing scientific evidence. In our study, we saw no evidence of a safety issue that would limit future studies. In this evaluation, CBD appears to be better tolerated than routine psychiatric medications. Furthermore, CBD displays promise as a tool for reducing anxiety in clinical populations, but given the open-label and nonrandomized nature of this large case series, all results must be interpreted very cautiously. Randomized and controlled trials are needed to provide definitive clinical guidance.
A Cross-Sectional Study of Cannabidiol Users
https://ncbi.nlm.nih.gov/pmc/articles/PMC6043845/
Results: Almost 62% of CBD users reported using CBD to treat a medical condition. The top three medical conditions were pain, anxiety, and depression. Almost 36% of respondents reported that CBD treats their medical condition(s) “very well by itself,” while only 4.3% reported “not very well.” One out of every three users reported a nonserious adverse effect. The odds of using CBD to treat a medical condition were 1.44 (95% confidence interval, 1.16–1.79) times greater among nonregular users of Cannabis than among regular users.
Conclusion: Consumers are using CBD as a specific therapy for multiple diverse medical conditions—particularly pain, anxiety, depression, and sleep disorders. These data provide a compelling rationale for further research to better understand the therapeutic potential of CBD.
Cannabidiol (CBD) — what we know and what we don’t
https://health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
Cannabidiol (CBD) has been recently covered in the media, and you may have even seen it as an add-in booster to your post-workout smoothie or morning coffee. What exactly is CBD? Why is it suddenly so popular?
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I'm not sure how "big pharma" has anything to do with this thread, including the articles you posted. I can't imagine that there are any companies that would be considered under the heading big pharma that produce CBD products (including medication I mentioned earlier today) and the legality surrounding CBD (and THC for that matter) isn't really related to big farma so much as it's related to illicit drug laws.GaleHawkins wrote: »NorthCascades wrote: »If you want to watch a hippie's head explode, tell them that if CBD really cured everything, "big pharma" would have never let "them" legalize it. 😆
The company Curaleaf claims that it has developed products that can treat a slew of the most formidable conditions found in humans, including cancer, Alzheimer’s, Parkinson’s, depression, opioid withdrawal, chronic pain, anxiety, post-traumatic stress disorder (PTSD), and attention deficit/hyperactivity disorder (ADHD). It also has products said to treat anxiety, pain, and diabetes in cats and dogs. (The product comes in bacon and salmon flavors.) And just one ingredient in all of its products is responsible for these remarkable medical breakthroughs: the cannabis-derived compound cannabidiol (CBD).
Sadly, those claims are not backed by evidence.
This week the Food and Drug Administration announced that it sent Curaleaf a warning letter for illegally selling unapproved drugs and making unsubstantiated treatment claims.
https://arstechnica.com/science/2019/07/a-cure-for-cancer-alzheimers-depression-fda-smacks-down-wild-cbd-claims/
@NorthCascades here are a few things that your "big pharma" knows about CBD from 45 years of research.
Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
https://ncbi.nlm.nih.gov/pmc/articles/PMC3232190/
"However, in this study we demonstrate that during intestinal inflammation, CBD is able to control the inflammatory scenario and the subsequent intestinal apoptosis through the restoration of the altered glia-immune homeostasis. CBD is therefore regarded as a promising therapeutic agent that modulates the neuro-immune axis, which can be recognised as a new target in the treatment of inflammatory bowel disorders."
An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
https://ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
After 45 years of research on CBD usage some of the disease states are name with CBD results on said disease states near the end of this paper.
Cannabidiol in Anxiety and Sleep: A Large Case Series
https://ncbi.nlm.nih.gov/pmc/articles/PMC6326553/
CONCLUSION
Formal studies on efficacy and dose finding are much needed. Some urgency exists, given the explosion of lay interest in this topic and the rush to market these compounds. Current understanding of the physiology and neurologic pathways points to a benefit with anxiety-related issues. The results of our clinical report support the existing scientific evidence. In our study, we saw no evidence of a safety issue that would limit future studies. In this evaluation, CBD appears to be better tolerated than routine psychiatric medications. Furthermore, CBD displays promise as a tool for reducing anxiety in clinical populations, but given the open-label and nonrandomized nature of this large case series, all results must be interpreted very cautiously. Randomized and controlled trials are needed to provide definitive clinical guidance.
A Cross-Sectional Study of Cannabidiol Users
https://ncbi.nlm.nih.gov/pmc/articles/PMC6043845/
Results: Almost 62% of CBD users reported using CBD to treat a medical condition. The top three medical conditions were pain, anxiety, and depression. Almost 36% of respondents reported that CBD treats their medical condition(s) “very well by itself,” while only 4.3% reported “not very well.” One out of every three users reported a nonserious adverse effect. The odds of using CBD to treat a medical condition were 1.44 (95% confidence interval, 1.16–1.79) times greater among nonregular users of Cannabis than among regular users.
Conclusion: Consumers are using CBD as a specific therapy for multiple diverse medical conditions—particularly pain, anxiety, depression, and sleep disorders. These data provide a compelling rationale for further research to better understand the therapeutic potential of CBD.
Cannabidiol (CBD) — what we know and what we don’t
https://health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
Cannabidiol (CBD) has been recently covered in the media, and you may have even seen it as an add-in booster to your post-workout smoothie or morning coffee. What exactly is CBD? Why is it suddenly so popular?
If this was one of the many other drugs that are also currently in the news, then that'd be one thing, but it's not.3 -
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Ironically enough, nystagmus is a more notorious side effect from Anti-epileptic drugsNorthCascades wrote: »
For the lols...
"Can nystagmus be treated?
Several medical and surgical treatments that sometimes help people with nystagmus are available. Surgery usually reduces the null positions, lessening head tilt and improving cosmetic appearance.
Drugs such as Botox or Baclofen can reduce some nystagmic movements, although results are usually temporary.
Some people with nystagmus benefit from biofeedback training.
If you have nystagmus, make sure you undergo regular eye exams so you can be monitored for both health and vision issues.
Both eyeglasses and contact lenses can help people with nystagmus see better, but I have found contact lenses to be the superior alternative for many with nystagmus. With glasses, the eyes sweep back and forth over the lens centers and vision is not as clear. With contacts, however, the lens centers move with the eyes."4 -
that's why i stick to wearing my thick a** glasses1
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I can't get that for 45% off this week at my favorite local Whole Foods like market!0 -
I can't get that for 45% off this week at my favorite local Whole Foods like market!
Michigan is in the honeymoon phase: You can't buy it for recreational use yet, but someone can give it to you as a gift, and you may possess it. So, potentially cheaper than the CBD.
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So, just to be semi on-topic, but maybe make y'all doubt my intelligence (even more than previously):
I am a person who likes N=1 experiments, in cases where there are a bunch of claims, but I'm pretty sure the thing in question has few risks. I try to keep an open mind, but a skeptical one.
Many of my friends were touting CBD oil for the joint pain of various types that's increasingly common in my demographic, so I decided to try it.
First, I tried the oral oil supplement for my knee pain. I can't see that it does anything at all. I've given it a fair chance. It tastes kind of bad, so you'd think I'd get some placebo effect for that alone, at least. But no.
Next, I tried the topical ointment. Early times with that one still, but as far as I can see so far, it has similar pain-relieving effect to any other ointment I rub in, i.e., I think it's the self-massage that's having a very limited and temporary effect ("feels good" ), rather than the nature of whatever I happen to rub into the knee.
FWIW. Which is pretty little, I think.4
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