Clearly CICO has no bearing on my recent weight loss

1457910

Replies

  • goldthistime
    goldthistime Posts: 3,214 Member
    psuLemon wrote: »
    blambo61 wrote: »
    davidylin wrote: »
    I knew a person that once lost 30 pounds while eating whatever he wanted. CICO is a lie, just like his phantom limb pain!

    CICO isn't a lie, we all obey thermodynamics, CICO just isn't the whole energy equation. CO really needs a clear definition. Excretion isn't part of the CICO equation but there are some calories lost that way.

    This might help you: http://ajcn.nutrition.org/content/95/4/989

    CICO is an representation of EE. People's misinterpretations of that doesn't make it any less relevant.

    Great link, thanks for sharing that.

  • JustRobby1
    JustRobby1 Posts: 674 Member
    OP here! My God people, these petty jabs and righteous posts leaves me to see that each and every one of you needs to pick up a newspaper and read about what is going on in the world - you know, beyond a life or death need to be right on this worn out subject!

    While I have a firm grasp of Physics, I posted because even after meticulous measuring of food and documenting exercise weekly, I only managed to see an 8 pound loss of weight after getting rid of gluten. And yeah, while you can lose weight with a CICO mindset while living on processed meats and junky sugar laden cakes and cookies, I wanted to express how efficiently my body is letting go of the excess fat with one basic and healthy change.

    And for all of you who will go red-faced at the mere mention of going gluten free, have at it - as for me, I know that my blood pressure is now an impressive 109/76 today, whereas five weeks ago it was a good 20 points higher. My arms and thighs have dropped an inch, my waist is down multiple inches and my face has never looked better or clearer.

    So all the defenders of the almighty CICO theory, keep up the petty squabbling - because it will surely bring change! For those interested in feeling a decade younger and/or dropping the thick middle, giving up gluten worked wonders for me and may very well for you too.

    Can I get you a glass of apple cider vinegar to wash that woo down with?
  • soda80
    soda80 Posts: 26 Member
    AnnPT77 "metabolic destiny of every actual calorie consumed"


    My new all-time favourite quote on MFP
  • psuLemon
    psuLemon Posts: 38,420 MFP Moderator
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    blambo61 wrote: »
    sgtx81 wrote: »
    What would be the point of logging if it didn't include your calories and macros? I assumed common sense would lead people to include those metrics in their log. And for ppl who plateau at 6 months or whatever though logging calories, they are either not being accurate or they are not accounting for the fact that the less they weigh, the fewer calories they need, so if they haven't been adjusting their intake accordingly they will notice a decline in weight loss and will eventually see it stop altogether.

    I don't believe I have ever seen anyone claim that keto increases metabolism. All I have ever seen is that it curbs appetite and causes the body to burn fat and protein for fuel instead of carbs. It may increase metabolism with increased physical activity, but more than that it changes how the metabolism functions.

    Everything short of liposuction is based on a caloric deficit. Different paths to the same goal. CICO is it, barring some disease or condition. Even then CICO is it, the condition may just modify the whole process in some way which would change the requirements for that person.

    Highlighted the important bit - I'm a living example of this. While my diabetes was untreated I lost 25 lbs in one month while eating everything I could and feeling like I was starving to death (because I literally was, due to my body's inability to metabolise glucose.)

    I was probably taking in 4000 calories a day, and my TDEE, based on my stats and what I needed to eat to maintain when my diabetes was finally diagnosed and treated, was lower than that. So despite eating at a surplus I was losing weight.

    Was this a violation of CICO? Well... in one sense yes. But in another sense, no, because the "CI" part just wasn't happening - the calories went in my mouth, sure, but instead of being metabolized and used by my body, they piled up in my blood until they could be filtered out by my kidneys. There's no simple way to measure what my CI was during this time, but it wasn't equal to the calorie value of the food I ate.

    CICO is a hard and fast rule, but there are circumstances, such as not being able to digest food properly, which make it difficult to accurately calculate calories in. There are other circumstances such as thyroid problems and medications which affect metabolism which make it difficult to calculate calories out.

    Exactly, CI in the mouth isn't the same as CI into fat cells. CO out of a fat cell are not the same as CO into the bloodstream available to do work due to ineficiencies of gluconeogensis. A lot of these disagreements, IMO, are due to not being clear on what me mean.

    Those things are in cico. We've told you many times before. Yet you come back and keep saying the same thing as if previous discussions never happened.

    Egads those things are not in CICO.

    CICO assumes CI in the mouth are all used for something which they are not. It also assumes that 100% of the caloric energy from fat is utilized to meet the bodies energy needs which it can't (it may make the body hotter when metabolized but it wasn't required to to meet any energy demand). CICO is a conservative model (for calculating deficits) by making these assumptions. If you stick to CICO, you should succeed because it is a conservative model. That doesn't mean you can't do better than CICO predicts and that things like LC or IF don't matter. I apologize to the OP for this big tangent. I'm done talking about this here.

    Maybe you should take the time and read the information i posted by Kevin Hall. CI refers to the metabolized components of food.

    I lied, I came back. It matters who you talk to what is included and what is not. A lot of folks here who say things like LC or IF make NO difference are obviously not including just the metabolized components, they are including every single calorie consumed. It is a matter of semantics I think that causes these debates.

    Its a matter of the studies which prove you wrong. When you equate for protein and calories, there is no difference. Your theories over the years have yet to be proven.

    The body is very complex obviously. Someone could just do the calculations, irrespective of studies, and show how much energy is required to digest certain food and how much is required to produce ketones and glucose from fat. Then it would be easy to see that based on timing of eating and what you eat, it will make a difference. The studies have so many confounding variable that confuse things. This problem can be tackled by just analysis alone to show that what and when will make a difference. 67% efficiency for gluconeogenis and probably 90+ % efficiency for digesting consumed glucose and what you eat makes no difference. It doesn't pass an analysis sanity check that those things make no difference.

    Dude, your own glucenogenisis study was a joke. Its showed an 11 calorie increase in EE, of which they alluded to 65% of that increase from increased protein.

    None of this disproves CICO. At best you can only say that there is no way to calculate CICO. Except you can use law of averages which is good enough. I have done it repeatedly. I know i maintain at about 3k.

    It didn't show 11 calorie increase:

    On average, in the H condition, 26 g extra glucose was produced through gluconeogenesis that resulted in an increase in EE of 0.144 MJ. The increase in EE after the H diet compared with the N diet was 0.340 ± 0.132 MJ. Thus, the contribution of increased gluconeogenesis to increased EE was 42%. Because the energy content of 26 g glucose is 0.442 MJ, the energy cost to produce glucose through gluconeogenesis was 33% of the energy content of glucose (95% CI: 16%, 50%).

    That's about a 100cal difference. Again for the umteenth time, I've stated IF and LC make SOME difference. I think it is significant (100 cals isn't in the noise and this didn't include IF). I don't know for sure how much a difference it makes but this study makes an attempt at quantifying that. The beef I have is when people on here say it makes NO difference (you should really state you THINK it makes LITTLE difference and you might be correct but you are wrong to say it make NO difference). The difference ISN"T ZERO. How big a difference is TBD.

    People shouldn't also get wigged out thinking I'm attacking CICO which I'm not. I've said numerous times that CICO is a worst case estimate (conservative estimate) for gains and losses and if you abide by it, you will get at least those losses and no more than the gains it predicts and to the extent of the difference IF/LC make, the loss or gain will be a little lower than what CICO predicts. I don't think what I've said is that difficult to understand so I don't know why people have an issue with it. Peoples attitude that nothing makes a difference squelches investigation as to how much a difference those things may make.

    Except your study didn't measure the differences in protein intake, they estimated it based on some values from other studies that KH did. So only a small portion of the increased EE was contributed to GNG.. Most of the estimated EE was due to an increase in protein intake, and only of which the participates ate 0% carbs (which is unlikely in a real life situation), while eating 171g of protein (in which most low carbers/ketoers won't do) and all while following a glycogen depletion workout (which again, has very little application.

    The bigger difference aren't related to IF/LC... they are related to protein content. When equating for calories, high protein diets have always shown an improvement in weight loss and metabolism. When you equate for protein and calories, there is no difference. So your predictions just haven't been shown. The high protein ones have been demonstrated time and time again.
  • blambo61
    blambo61 Posts: 4,372 Member
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    blambo61 wrote: »
    sgtx81 wrote: »
    What would be the point of logging if it didn't include your calories and macros? I assumed common sense would lead people to include those metrics in their log. And for ppl who plateau at 6 months or whatever though logging calories, they are either not being accurate or they are not accounting for the fact that the less they weigh, the fewer calories they need, so if they haven't been adjusting their intake accordingly they will notice a decline in weight loss and will eventually see it stop altogether.

    I don't believe I have ever seen anyone claim that keto increases metabolism. All I have ever seen is that it curbs appetite and causes the body to burn fat and protein for fuel instead of carbs. It may increase metabolism with increased physical activity, but more than that it changes how the metabolism functions.

    Everything short of liposuction is based on a caloric deficit. Different paths to the same goal. CICO is it, barring some disease or condition. Even then CICO is it, the condition may just modify the whole process in some way which would change the requirements for that person.

    Highlighted the important bit - I'm a living example of this. While my diabetes was untreated I lost 25 lbs in one month while eating everything I could and feeling like I was starving to death (because I literally was, due to my body's inability to metabolise glucose.)

    I was probably taking in 4000 calories a day, and my TDEE, based on my stats and what I needed to eat to maintain when my diabetes was finally diagnosed and treated, was lower than that. So despite eating at a surplus I was losing weight.

    Was this a violation of CICO? Well... in one sense yes. But in another sense, no, because the "CI" part just wasn't happening - the calories went in my mouth, sure, but instead of being metabolized and used by my body, they piled up in my blood until they could be filtered out by my kidneys. There's no simple way to measure what my CI was during this time, but it wasn't equal to the calorie value of the food I ate.

    CICO is a hard and fast rule, but there are circumstances, such as not being able to digest food properly, which make it difficult to accurately calculate calories in. There are other circumstances such as thyroid problems and medications which affect metabolism which make it difficult to calculate calories out.

    Exactly, CI in the mouth isn't the same as CI into fat cells. CO out of a fat cell are not the same as CO into the bloodstream available to do work due to ineficiencies of gluconeogensis. A lot of these disagreements, IMO, are due to not being clear on what me mean.

    Those things are in cico. We've told you many times before. Yet you come back and keep saying the same thing as if previous discussions never happened.

    Egads those things are not in CICO.

    CICO assumes CI in the mouth are all used for something which they are not. It also assumes that 100% of the caloric energy from fat is utilized to meet the bodies energy needs which it can't (it may make the body hotter when metabolized but it wasn't required to to meet any energy demand). CICO is a conservative model (for calculating deficits) by making these assumptions. If you stick to CICO, you should succeed because it is a conservative model. That doesn't mean you can't do better than CICO predicts and that things like LC or IF don't matter. I apologize to the OP for this big tangent. I'm done talking about this here.

    Maybe you should take the time and read the information i posted by Kevin Hall. CI refers to the metabolized components of food.

    I lied, I came back. It matters who you talk to what is included and what is not. A lot of folks here who say things like LC or IF make NO difference are obviously not including just the metabolized components, they are including every single calorie consumed. It is a matter of semantics I think that causes these debates.

    Its a matter of the studies which prove you wrong. When you equate for protein and calories, there is no difference. Your theories over the years have yet to be proven.

    The body is very complex obviously. Someone could just do the calculations, irrespective of studies, and show how much energy is required to digest certain food and how much is required to produce ketones and glucose from fat. Then it would be easy to see that based on timing of eating and what you eat, it will make a difference. The studies have so many confounding variable that confuse things. This problem can be tackled by just analysis alone to show that what and when will make a difference. 67% efficiency for gluconeogenis and probably 90+ % efficiency for digesting consumed glucose and what you eat makes no difference. It doesn't pass an analysis sanity check that those things make no difference.

    Dude, your own glucenogenisis study was a joke. Its showed an 11 calorie increase in EE, of which they alluded to 65% of that increase from increased protein.

    None of this disproves CICO. At best you can only say that there is no way to calculate CICO. Except you can use law of averages which is good enough. I have done it repeatedly. I know i maintain at about 3k.

    It didn't show 11 calorie increase:

    On average, in the H condition, 26 g extra glucose was produced through gluconeogenesis that resulted in an increase in EE of 0.144 MJ. The increase in EE after the H diet compared with the N diet was 0.340 ± 0.132 MJ. Thus, the contribution of increased gluconeogenesis to increased EE was 42%. Because the energy content of 26 g glucose is 0.442 MJ, the energy cost to produce glucose through gluconeogenesis was 33% of the energy content of glucose (95% CI: 16%, 50%).

    That's about a 100cal difference. Again for the umteenth time, I've stated IF and LC make SOME difference. I think it is significant (100 cals isn't in the noise and this didn't include IF). I don't know for sure how much a difference it makes but this study makes an attempt at quantifying that. The beef I have is when people on here say it makes NO difference (you should really state you THINK it makes LITTLE difference and you might be correct but you are wrong to say it make NO difference). The difference ISN"T ZERO. How big a difference is TBD.

    People shouldn't also get wigged out thinking I'm attacking CICO which I'm not. I've said numerous times that CICO is a worst case estimate (conservative estimate) for gains and losses and if you abide by it, you will get at least those losses and no more than the gains it predicts and to the extent of the difference IF/LC make, the loss or gain will be a little lower than what CICO predicts. I don't think what I've said is that difficult to understand so I don't know why people have an issue with it. Peoples attitude that nothing makes a difference squelches investigation as to how much a difference those things may make.

    Except your study didn't measure the differences in protein intake, they estimated it based on some values from other studies that KH did. So only a small portion of the increased EE was contributed to GNG.. Most of the estimated EE was due to an increase in protein intake, and only of which the participates ate 0% carbs (which is unlikely in a real life situation), while eating 171g of protein (in which most low carbers/ketoers won't do) and all while following a glycogen depletion workout (which again, has very little application.

    The bigger difference aren't related to IF/LC... they are related to protein content. When equating for calories, high protein diets have always shown an improvement in weight loss and metabolism. When you equate for protein and calories, there is no difference. So your predictions just haven't been shown. The high protein ones have been demonstrated time and time again.

    The results said 26g more of gluconeogenesis. I don't believe that was due to the protein intake. That was separate from the protein effects which was additional EE.

    Bottom line, you just stated what I've been stating, that what you eat does matter.
  • psuLemon
    psuLemon Posts: 38,420 MFP Moderator
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    blambo61 wrote: »
    sgtx81 wrote: »
    What would be the point of logging if it didn't include your calories and macros? I assumed common sense would lead people to include those metrics in their log. And for ppl who plateau at 6 months or whatever though logging calories, they are either not being accurate or they are not accounting for the fact that the less they weigh, the fewer calories they need, so if they haven't been adjusting their intake accordingly they will notice a decline in weight loss and will eventually see it stop altogether.

    I don't believe I have ever seen anyone claim that keto increases metabolism. All I have ever seen is that it curbs appetite and causes the body to burn fat and protein for fuel instead of carbs. It may increase metabolism with increased physical activity, but more than that it changes how the metabolism functions.

    Everything short of liposuction is based on a caloric deficit. Different paths to the same goal. CICO is it, barring some disease or condition. Even then CICO is it, the condition may just modify the whole process in some way which would change the requirements for that person.

    Highlighted the important bit - I'm a living example of this. While my diabetes was untreated I lost 25 lbs in one month while eating everything I could and feeling like I was starving to death (because I literally was, due to my body's inability to metabolise glucose.)

    I was probably taking in 4000 calories a day, and my TDEE, based on my stats and what I needed to eat to maintain when my diabetes was finally diagnosed and treated, was lower than that. So despite eating at a surplus I was losing weight.

    Was this a violation of CICO? Well... in one sense yes. But in another sense, no, because the "CI" part just wasn't happening - the calories went in my mouth, sure, but instead of being metabolized and used by my body, they piled up in my blood until they could be filtered out by my kidneys. There's no simple way to measure what my CI was during this time, but it wasn't equal to the calorie value of the food I ate.

    CICO is a hard and fast rule, but there are circumstances, such as not being able to digest food properly, which make it difficult to accurately calculate calories in. There are other circumstances such as thyroid problems and medications which affect metabolism which make it difficult to calculate calories out.

    Exactly, CI in the mouth isn't the same as CI into fat cells. CO out of a fat cell are not the same as CO into the bloodstream available to do work due to ineficiencies of gluconeogensis. A lot of these disagreements, IMO, are due to not being clear on what me mean.

    Those things are in cico. We've told you many times before. Yet you come back and keep saying the same thing as if previous discussions never happened.

    Egads those things are not in CICO.

    CICO assumes CI in the mouth are all used for something which they are not. It also assumes that 100% of the caloric energy from fat is utilized to meet the bodies energy needs which it can't (it may make the body hotter when metabolized but it wasn't required to to meet any energy demand). CICO is a conservative model (for calculating deficits) by making these assumptions. If you stick to CICO, you should succeed because it is a conservative model. That doesn't mean you can't do better than CICO predicts and that things like LC or IF don't matter. I apologize to the OP for this big tangent. I'm done talking about this here.

    Maybe you should take the time and read the information i posted by Kevin Hall. CI refers to the metabolized components of food.

    I lied, I came back. It matters who you talk to what is included and what is not. A lot of folks here who say things like LC or IF make NO difference are obviously not including just the metabolized components, they are including every single calorie consumed. It is a matter of semantics I think that causes these debates.

    Its a matter of the studies which prove you wrong. When you equate for protein and calories, there is no difference. Your theories over the years have yet to be proven.

    The body is very complex obviously. Someone could just do the calculations, irrespective of studies, and show how much energy is required to digest certain food and how much is required to produce ketones and glucose from fat. Then it would be easy to see that based on timing of eating and what you eat, it will make a difference. The studies have so many confounding variable that confuse things. This problem can be tackled by just analysis alone to show that what and when will make a difference. 67% efficiency for gluconeogenis and probably 90+ % efficiency for digesting consumed glucose and what you eat makes no difference. It doesn't pass an analysis sanity check that those things make no difference.

    Dude, your own glucenogenisis study was a joke. Its showed an 11 calorie increase in EE, of which they alluded to 65% of that increase from increased protein.

    None of this disproves CICO. At best you can only say that there is no way to calculate CICO. Except you can use law of averages which is good enough. I have done it repeatedly. I know i maintain at about 3k.

    It didn't show 11 calorie increase:

    On average, in the H condition, 26 g extra glucose was produced through gluconeogenesis that resulted in an increase in EE of 0.144 MJ. The increase in EE after the H diet compared with the N diet was 0.340 ± 0.132 MJ. Thus, the contribution of increased gluconeogenesis to increased EE was 42%. Because the energy content of 26 g glucose is 0.442 MJ, the energy cost to produce glucose through gluconeogenesis was 33% of the energy content of glucose (95% CI: 16%, 50%).

    That's about a 100cal difference. Again for the umteenth time, I've stated IF and LC make SOME difference. I think it is significant (100 cals isn't in the noise and this didn't include IF). I don't know for sure how much a difference it makes but this study makes an attempt at quantifying that. The beef I have is when people on here say it makes NO difference (you should really state you THINK it makes LITTLE difference and you might be correct but you are wrong to say it make NO difference). The difference ISN"T ZERO. How big a difference is TBD.

    People shouldn't also get wigged out thinking I'm attacking CICO which I'm not. I've said numerous times that CICO is a worst case estimate (conservative estimate) for gains and losses and if you abide by it, you will get at least those losses and no more than the gains it predicts and to the extent of the difference IF/LC make, the loss or gain will be a little lower than what CICO predicts. I don't think what I've said is that difficult to understand so I don't know why people have an issue with it. Peoples attitude that nothing makes a difference squelches investigation as to how much a difference those things may make.

    Except your study didn't measure the differences in protein intake, they estimated it based on some values from other studies that KH did. So only a small portion of the increased EE was contributed to GNG.. Most of the estimated EE was due to an increase in protein intake, and only of which the participates ate 0% carbs (which is unlikely in a real life situation), while eating 171g of protein (in which most low carbers/ketoers won't do) and all while following a glycogen depletion workout (which again, has very little application.

    The bigger difference aren't related to IF/LC... they are related to protein content. When equating for calories, high protein diets have always shown an improvement in weight loss and metabolism. When you equate for protein and calories, there is no difference. So your predictions just haven't been shown. The high protein ones have been demonstrated time and time again.

    The results said 26g more of gluconeogenesis. I don't believe that was due to the protein intake. That was separate from the protein effects which was additional EE.

    Bottom line, you just stated what I've been stating, that what you eat does matter.

    If what we are eating is protein, it does matter. But IF and LC have nothing to do with that. And if you look at your study, it does point out that the increase in EE was only 42% from GNG (so at best 40 calories).
  • blambo61
    blambo61 Posts: 4,372 Member
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    blambo61 wrote: »
    sgtx81 wrote: »
    What would be the point of logging if it didn't include your calories and macros? I assumed common sense would lead people to include those metrics in their log. And for ppl who plateau at 6 months or whatever though logging calories, they are either not being accurate or they are not accounting for the fact that the less they weigh, the fewer calories they need, so if they haven't been adjusting their intake accordingly they will notice a decline in weight loss and will eventually see it stop altogether.

    I don't believe I have ever seen anyone claim that keto increases metabolism. All I have ever seen is that it curbs appetite and causes the body to burn fat and protein for fuel instead of carbs. It may increase metabolism with increased physical activity, but more than that it changes how the metabolism functions.

    Everything short of liposuction is based on a caloric deficit. Different paths to the same goal. CICO is it, barring some disease or condition. Even then CICO is it, the condition may just modify the whole process in some way which would change the requirements for that person.

    Highlighted the important bit - I'm a living example of this. While my diabetes was untreated I lost 25 lbs in one month while eating everything I could and feeling like I was starving to death (because I literally was, due to my body's inability to metabolise glucose.)

    I was probably taking in 4000 calories a day, and my TDEE, based on my stats and what I needed to eat to maintain when my diabetes was finally diagnosed and treated, was lower than that. So despite eating at a surplus I was losing weight.

    Was this a violation of CICO? Well... in one sense yes. But in another sense, no, because the "CI" part just wasn't happening - the calories went in my mouth, sure, but instead of being metabolized and used by my body, they piled up in my blood until they could be filtered out by my kidneys. There's no simple way to measure what my CI was during this time, but it wasn't equal to the calorie value of the food I ate.

    CICO is a hard and fast rule, but there are circumstances, such as not being able to digest food properly, which make it difficult to accurately calculate calories in. There are other circumstances such as thyroid problems and medications which affect metabolism which make it difficult to calculate calories out.

    Exactly, CI in the mouth isn't the same as CI into fat cells. CO out of a fat cell are not the same as CO into the bloodstream available to do work due to ineficiencies of gluconeogensis. A lot of these disagreements, IMO, are due to not being clear on what me mean.

    Those things are in cico. We've told you many times before. Yet you come back and keep saying the same thing as if previous discussions never happened.

    Egads those things are not in CICO.

    CICO assumes CI in the mouth are all used for something which they are not. It also assumes that 100% of the caloric energy from fat is utilized to meet the bodies energy needs which it can't (it may make the body hotter when metabolized but it wasn't required to to meet any energy demand). CICO is a conservative model (for calculating deficits) by making these assumptions. If you stick to CICO, you should succeed because it is a conservative model. That doesn't mean you can't do better than CICO predicts and that things like LC or IF don't matter. I apologize to the OP for this big tangent. I'm done talking about this here.

    Maybe you should take the time and read the information i posted by Kevin Hall. CI refers to the metabolized components of food.

    I lied, I came back. It matters who you talk to what is included and what is not. A lot of folks here who say things like LC or IF make NO difference are obviously not including just the metabolized components, they are including every single calorie consumed. It is a matter of semantics I think that causes these debates.

    Its a matter of the studies which prove you wrong. When you equate for protein and calories, there is no difference. Your theories over the years have yet to be proven.

    The body is very complex obviously. Someone could just do the calculations, irrespective of studies, and show how much energy is required to digest certain food and how much is required to produce ketones and glucose from fat. Then it would be easy to see that based on timing of eating and what you eat, it will make a difference. The studies have so many confounding variable that confuse things. This problem can be tackled by just analysis alone to show that what and when will make a difference. 67% efficiency for gluconeogenis and probably 90+ % efficiency for digesting consumed glucose and what you eat makes no difference. It doesn't pass an analysis sanity check that those things make no difference.

    Dude, your own glucenogenisis study was a joke. Its showed an 11 calorie increase in EE, of which they alluded to 65% of that increase from increased protein.

    None of this disproves CICO. At best you can only say that there is no way to calculate CICO. Except you can use law of averages which is good enough. I have done it repeatedly. I know i maintain at about 3k.

    It didn't show 11 calorie increase:

    On average, in the H condition, 26 g extra glucose was produced through gluconeogenesis that resulted in an increase in EE of 0.144 MJ. The increase in EE after the H diet compared with the N diet was 0.340 ± 0.132 MJ. Thus, the contribution of increased gluconeogenesis to increased EE was 42%. Because the energy content of 26 g glucose is 0.442 MJ, the energy cost to produce glucose through gluconeogenesis was 33% of the energy content of glucose (95% CI: 16%, 50%).

    That's about a 100cal difference. Again for the umteenth time, I've stated IF and LC make SOME difference. I think it is significant (100 cals isn't in the noise and this didn't include IF). I don't know for sure how much a difference it makes but this study makes an attempt at quantifying that. The beef I have is when people on here say it makes NO difference (you should really state you THINK it makes LITTLE difference and you might be correct but you are wrong to say it make NO difference). The difference ISN"T ZERO. How big a difference is TBD.

    People shouldn't also get wigged out thinking I'm attacking CICO which I'm not. I've said numerous times that CICO is a worst case estimate (conservative estimate) for gains and losses and if you abide by it, you will get at least those losses and no more than the gains it predicts and to the extent of the difference IF/LC make, the loss or gain will be a little lower than what CICO predicts. I don't think what I've said is that difficult to understand so I don't know why people have an issue with it. Peoples attitude that nothing makes a difference squelches investigation as to how much a difference those things may make.

    Except your study didn't measure the differences in protein intake, they estimated it based on some values from other studies that KH did. So only a small portion of the increased EE was contributed to GNG.. Most of the estimated EE was due to an increase in protein intake, and only of which the participates ate 0% carbs (which is unlikely in a real life situation), while eating 171g of protein (in which most low carbers/ketoers won't do) and all while following a glycogen depletion workout (which again, has very little application.

    The bigger difference aren't related to IF/LC... they are related to protein content. When equating for calories, high protein diets have always shown an improvement in weight loss and metabolism. When you equate for protein and calories, there is no difference. So your predictions just haven't been shown. The high protein ones have been demonstrated time and time again.

    The results said 26g more of gluconeogenesis. I don't believe that was due to the protein intake. That was separate from the protein effects which was additional EE.

    Bottom line, you just stated what I've been stating, that what you eat does matter.

    If what we are eating is protein, it does matter. But IF and LC have nothing to do with that. And if you look at your study, it does point out that the increase in EE was only 42% from GNG (so at best 40 calories).

    I don't think the extra gluconeogenisis was due to the protein diet. It was due to the lack of carbs. I think that
    is the correct interpretation so it would be about 100kcals difference. LC and IF will result in more gluconeogenisis due to being in a state of low carb consumption so this study is applicable to those two things.
  • WinoGelato
    WinoGelato Posts: 13,454 Member
    @blambo61 in thread after thread like this, you state that you agree that CICO works and that you aren't trying to disprove it, you seem to be saying that it's possible to go above and beyond the rate of loss someone would get from just the basic calorie deficit if they follow IF and/or a LCHF diet. People keep telling you that any additional benefits would either be negligible, or temporary, or just not be worth the extra effort if someone doesn't enjoy doing IF or eating LC. You disagree and keep touting studies about glucogenesis, in the past, if I recall, it was TEF and excretion you were focusing on.

    My question is, what have your results been, since clearly you're so passionate about dialing in your results to maximize every potential fraction of a calorie burn. How long have you been on your weight loss journey? How much weight did you have to lose? How much have you lost and in what time period? Is the loss consistent from week to week?

    I assume since you're so focused on the details that you've been holding protein and other variables constant, so that you really can prove that these things matter.... so what have your results been so far? Are you losing at 1.5 lbs/week instead of a predicted 1 lb/week? 1.25 lb/week? 1.1 lb/week? You keep saying the advantage is not insignificant, but I would like to see it expressed in how much extra a person could lose in the same time period so people can assess whether the extra trouble is worth going to or not.

    Thanks in advance for sharing the results of your experiment!
  • psuLemon
    psuLemon Posts: 38,420 MFP Moderator
    edited October 2017
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    psuLemon wrote: »
    blambo61 wrote: »
    blambo61 wrote: »
    sgtx81 wrote: »
    What would be the point of logging if it didn't include your calories and macros? I assumed common sense would lead people to include those metrics in their log. And for ppl who plateau at 6 months or whatever though logging calories, they are either not being accurate or they are not accounting for the fact that the less they weigh, the fewer calories they need, so if they haven't been adjusting their intake accordingly they will notice a decline in weight loss and will eventually see it stop altogether.

    I don't believe I have ever seen anyone claim that keto increases metabolism. All I have ever seen is that it curbs appetite and causes the body to burn fat and protein for fuel instead of carbs. It may increase metabolism with increased physical activity, but more than that it changes how the metabolism functions.

    Everything short of liposuction is based on a caloric deficit. Different paths to the same goal. CICO is it, barring some disease or condition. Even then CICO is it, the condition may just modify the whole process in some way which would change the requirements for that person.

    Highlighted the important bit - I'm a living example of this. While my diabetes was untreated I lost 25 lbs in one month while eating everything I could and feeling like I was starving to death (because I literally was, due to my body's inability to metabolise glucose.)

    I was probably taking in 4000 calories a day, and my TDEE, based on my stats and what I needed to eat to maintain when my diabetes was finally diagnosed and treated, was lower than that. So despite eating at a surplus I was losing weight.

    Was this a violation of CICO? Well... in one sense yes. But in another sense, no, because the "CI" part just wasn't happening - the calories went in my mouth, sure, but instead of being metabolized and used by my body, they piled up in my blood until they could be filtered out by my kidneys. There's no simple way to measure what my CI was during this time, but it wasn't equal to the calorie value of the food I ate.

    CICO is a hard and fast rule, but there are circumstances, such as not being able to digest food properly, which make it difficult to accurately calculate calories in. There are other circumstances such as thyroid problems and medications which affect metabolism which make it difficult to calculate calories out.

    Exactly, CI in the mouth isn't the same as CI into fat cells. CO out of a fat cell are not the same as CO into the bloodstream available to do work due to ineficiencies of gluconeogensis. A lot of these disagreements, IMO, are due to not being clear on what me mean.

    Those things are in cico. We've told you many times before. Yet you come back and keep saying the same thing as if previous discussions never happened.

    Egads those things are not in CICO.

    CICO assumes CI in the mouth are all used for something which they are not. It also assumes that 100% of the caloric energy from fat is utilized to meet the bodies energy needs which it can't (it may make the body hotter when metabolized but it wasn't required to to meet any energy demand). CICO is a conservative model (for calculating deficits) by making these assumptions. If you stick to CICO, you should succeed because it is a conservative model. That doesn't mean you can't do better than CICO predicts and that things like LC or IF don't matter. I apologize to the OP for this big tangent. I'm done talking about this here.

    Maybe you should take the time and read the information i posted by Kevin Hall. CI refers to the metabolized components of food.

    I lied, I came back. It matters who you talk to what is included and what is not. A lot of folks here who say things like LC or IF make NO difference are obviously not including just the metabolized components, they are including every single calorie consumed. It is a matter of semantics I think that causes these debates.

    Its a matter of the studies which prove you wrong. When you equate for protein and calories, there is no difference. Your theories over the years have yet to be proven.

    The body is very complex obviously. Someone could just do the calculations, irrespective of studies, and show how much energy is required to digest certain food and how much is required to produce ketones and glucose from fat. Then it would be easy to see that based on timing of eating and what you eat, it will make a difference. The studies have so many confounding variable that confuse things. This problem can be tackled by just analysis alone to show that what and when will make a difference. 67% efficiency for gluconeogenis and probably 90+ % efficiency for digesting consumed glucose and what you eat makes no difference. It doesn't pass an analysis sanity check that those things make no difference.

    Dude, your own glucenogenisis study was a joke. Its showed an 11 calorie increase in EE, of which they alluded to 65% of that increase from increased protein.

    None of this disproves CICO. At best you can only say that there is no way to calculate CICO. Except you can use law of averages which is good enough. I have done it repeatedly. I know i maintain at about 3k.

    It didn't show 11 calorie increase:

    On average, in the H condition, 26 g extra glucose was produced through gluconeogenesis that resulted in an increase in EE of 0.144 MJ. The increase in EE after the H diet compared with the N diet was 0.340 ± 0.132 MJ. Thus, the contribution of increased gluconeogenesis to increased EE was 42%. Because the energy content of 26 g glucose is 0.442 MJ, the energy cost to produce glucose through gluconeogenesis was 33% of the energy content of glucose (95% CI: 16%, 50%).

    That's about a 100cal difference. Again for the umteenth time, I've stated IF and LC make SOME difference. I think it is significant (100 cals isn't in the noise and this didn't include IF). I don't know for sure how much a difference it makes but this study makes an attempt at quantifying that. The beef I have is when people on here say it makes NO difference (you should really state you THINK it makes LITTLE difference and you might be correct but you are wrong to say it make NO difference). The difference ISN"T ZERO. How big a difference is TBD.

    People shouldn't also get wigged out thinking I'm attacking CICO which I'm not. I've said numerous times that CICO is a worst case estimate (conservative estimate) for gains and losses and if you abide by it, you will get at least those losses and no more than the gains it predicts and to the extent of the difference IF/LC make, the loss or gain will be a little lower than what CICO predicts. I don't think what I've said is that difficult to understand so I don't know why people have an issue with it. Peoples attitude that nothing makes a difference squelches investigation as to how much a difference those things may make.

    Except your study didn't measure the differences in protein intake, they estimated it based on some values from other studies that KH did. So only a small portion of the increased EE was contributed to GNG.. Most of the estimated EE was due to an increase in protein intake, and only of which the participates ate 0% carbs (which is unlikely in a real life situation), while eating 171g of protein (in which most low carbers/ketoers won't do) and all while following a glycogen depletion workout (which again, has very little application.

    The bigger difference aren't related to IF/LC... they are related to protein content. When equating for calories, high protein diets have always shown an improvement in weight loss and metabolism. When you equate for protein and calories, there is no difference. So your predictions just haven't been shown. The high protein ones have been demonstrated time and time again.

    The results said 26g more of gluconeogenesis. I don't believe that was due to the protein intake. That was separate from the protein effects which was additional EE.

    Bottom line, you just stated what I've been stating, that what you eat does matter.

    If what we are eating is protein, it does matter. But IF and LC have nothing to do with that. And if you look at your study, it does point out that the increase in EE was only 42% from GNG (so at best 40 calories).

    I don't think the extra gluconeogenisis was due to the protein diet. It was due to the lack of carbs. I think that
    is the correct interpretation so it would be about 100kcals difference. LC and IF will result in more gluconeogenisis due to being in a state of low carb consumption so this study is applicable to those two things.

    They forced gng due to depleting glycogen and not eating carbs. It used protein to convert to glycogen. It does so as a protective mechanism to ensure a fuel is provided. This does not occur unless it has to. No difference the the body creating SFA from carbs.

    Ideally, they would have controlled calories and protein to not induce a thermogenic effect from protein. But they didnt. This was merely a investigative study. And without controlling for the additional variables, it can only be hypothesized. Also, they clearly state several times that not all of the EE ia from GNG.

    Ultimately, the application is not there. Most people consume some level of carba which will store as glycogen in the liver or muscles. But even if you do get some effect, why would you want protein to convert to glucose?


    ETA: "In conclusion, increased gluconeogenesis contributes to increased EE after consumption of an H diet for 1.5 d following a decrease in body glycogen stores. Forty-two percent of the increase in EE after the H diet was explained by an increase in gluconeogenesis. The energy cost of gluconeogenesis was 33% of the energy content of glucose?

    And "The energy costs of protein synthesis and protein breakdown have been estimated from theoretical values to be 3.6 and 0.7 kJ/g, respectively. Nevertheless, they have not actually been measured, and the contribution of these pathways to increased EE with a high-protein diet requires further study. Previously, it has been shown from a theoretical perspective that an increased demand on protein and amino acid turnover for gluconeogenesis by a low-carbohydrate diet increases EE"
  • blambo61
    blambo61 Posts: 4,372 Member
    edited October 2017
    WinoGelato wrote: »
    @blambo61 in thread after thread like this, you state that you agree that CICO works and that you aren't trying to disprove it, you seem to be saying that it's possible to go above and beyond the rate of loss someone would get from just the basic calorie deficit if they follow IF and/or a LCHF diet. People keep telling you that any additional benefits would either be negligible, or temporary, or just not be worth the extra effort if someone doesn't enjoy doing IF or eating LC. You disagree and keep touting studies about glucogenesis, in the past, if I recall, it was TEF and excretion you were focusing on.

    My question is, what have your results been, since clearly you're so passionate about dialing in your results to maximize every potential fraction of a calorie burn. How long have you been on your weight loss journey? How much weight did you have to lose? How much have you lost and in what time period? Is the loss consistent from week to week?

    I assume since you're so focused on the details that you've been holding protein and other variables constant, so that you really can prove that these things matter.... so what have your results been so far? Are you losing at 1.5 lbs/week instead of a predicted 1 lb/week? 1.25 lb/week? 1.1 lb/week? You keep saying the advantage is not insignificant, but I would like to see it expressed in how much extra a person could lose in the same time period so people can assess whether the extra trouble is worth going to or not.

    Thanks in advance for sharing the results of your experiment!

    The study I just posted looks like LC makes about 100kcal difference a day due to LC for the people the experiment was run on. IF wasn't addressed which I think would be an even bigger contribution.
    If both were done and it resulted in a 200-300 kcal/day difference, would that not be significant?

    My BMR is supposed to be about 2000kcal/day (by impedance measurements and by MFP predictions) or about 90-kcal/hr. If I do a 20:4 IF, I imagine that I'm doing gluconeogenisis about 16-hrs of that time. That would be about 90x16 cals produced that way (some of the cals I'm running on would be keytones also so the numbers for gluconeogensis wouldn't be that high but I'm sure there is some inneficiencies producing those also) which is about 1440kcals. 33% of that number is about 480kcals/day (losses due to inefficiencies). Someone eating a high carb continuous diet would be performing gluconeogenesis for a much shorter time, maybe 4-hrs at the end of their sleep so the difference between these extremes could be about 360kcals/day. That is a ball park estimate for just IF. LC combined would make the time in gluconeogenis even longer by about 4-hrs in this example so both together could be back to about 480kcals/day. None of this addresses rate and saturation limits on properly digesting the food consumed during a 4-hr eating window which could even further increase a deficit. Those are significant numbers.

    My main point is, a lot of people say it makes NO difference which flies in the face of any reasoning. That attitude stifles looking into the magnitude of the differences it makes. I don't know how much a difference it makes but I do know the difference is not ZERO. Anyone who thinks that does not have a basic understanding of thermodynamics. You can't take electricity, do electrolysis with it, take the hydrogen and oxygen produced with the electrolysis, burn it to turn a steam turbine and end up with the same amount of electrical energy you started with! There are losses. Going from food to fat to glucose results in losses. 33% losses according to the study I provided.

    People lump all these other effects into BMR which is in error. They will calculate CI the mouth, energy expenditures and calculate BMR from that. The example of the diabetic shows that is the wrong approach because they don't aborb food (without insulin) and it is excreted. Their basal metabolic needs didn't use those calories up. Same with losses from gluconeogenisis, they may make your body hotter, but they were not used up from an an external energy demand from the body and would not be necessary if carbs where present.

    My experience won't prove anything, but I have lost at a greater rate than what MFP predicted. I lost about 45-lbs in 5-months. I did count calories and by the BMR estimate I was given and the exercise and steps I did, I lost about 1-lb more/week than it said I should. There are MANY more people, some I read about today even, that did detailed calorie counting for a long time and plateaued then started a 5:2 IF diet and started losing while continuing the counting as they had done before. That doesn't necessarily prove anything either since it wasn't a controlled experiment, but there is tons of antecdotal evidence, which may indicate causality. I maintained for 1.5 years after the initial weight loss and now I've lost 13-lbs in the last 8 weeks after going back on my 20:4 IF diet. I maintained on a 16:8 IF diet. I eat ad libitum in the evenings and I don't count calories very much. I probably eat about 2000-2400kcal/day (mostly 2400/day) based on the few days I have counted. I run 4xweek for about 20-miles/week. My estimated TDEE is 2700kcal/day (I have a smart gps watch that gives me steps and running estimates - I do run hills once a week which it will underestimate). For the last 8-wks my average loss is 1.62-lbs/week which would require a minimum of an 810kcal deficit/day (my losses were 2-lbs week except for two of the weeks I didn't keep the diet everyday due to a marriage in the family and some other circumstances). There is no way I'm eating only 1900 kcals/day on the average guaranteed! For me, there is an unexplained difference of about 300kcal or more/day which coincides well with my gestimate above. When I was at 2-lbs loss/day (doing IF everyday), the unexplained difference was about 300-700kcal/day.

    I don't have a problem with people saying they think the factors mentioned are insignificant (TBD) but I do have a problem when they say they don't exist.