Interesting Studies: Probably low carb related in one way or another
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Kevin Hall on Metabolic Adaptations to Weight Loss
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Therapeutic use of carbohydrate-restricted diets in an autistic child; a case report of clinical and 18FDG PET findings
In the case presented here, glucose hypometabolism in discrete brain structures, as revealed by 18F-FDG PET, was observed at baseline and was further decreased after the patient continued on the KD for approximately 12 months. This decrease was potentially caused by a metabolic shift from the utilization of glucose to utilization of ketone bodies as a primary source of energy (Frye and Rossignol 2014; Courchesne-Loyer et al. 2017).
Likewise, the patient’s behaviour and intellect improved when on the KD.
Further exploration will study whether autistic patients exhibiting similar glucose hypometabolism in 18F-FDG PET would attain similar clinical benefits on the KD. Of note, other medical conditions (e.g., Alzheimer’s disease, mild cognitive impairment, or amyotrophic lateral sclerosis) associated with glucose hypometabolism are now thought to benefit from the KD or other approaches (e.g., ketone bodies, their metabolic precursors, or medium-chain-fatty acids) that affect glucose/lipid metabolism in a way that at least partially mimics the KD (Croteau et al. 2017; Koppel and Swerdlow 2017; Paoli et al. 2014).
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A system view and analysis of essential hypertension
Our analysis suggests that insulin plays a primary role in hypertension, highlighting the tight link between essential hypertension and diseases associated with the metabolic syndrome.
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Effects of a 4-Week Very Low-Carbohydrate Diet on High-Intensity Interval Training Responses
Key Points- A group of participants that changed from habitual mixed western-based to VLCHF diet over 4 weeks substantially increased rates of fat oxidation shown during a graded exercise test and high-intensity interval training (HIIT) session.
- Performance and cardiorespiratory responses during a graded exercise test and HIIT were not impaired after consuming a VLCHF diet relative to a group consuming their mixed western-based diet.
- A four-week adaptation period to a VLCHF diet preserved high-intensity exercise performance.
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Nice. It's great to see more research being done on sports performance and lchf and Keto. And research that allows for a fat adaptation stage!1
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Re: Typeonegrit (group that follows Dr. Bernstein's recommendations w/ excellent results).
Management of Type 1 Diabetes with a Very Low Carbohydrate Diet
Conclusions: Exceptional glycemic control of T1DM with low rates of adverse events was reported by a community of children and adults who consume a VLCD. The generalizability of these findings requires further studies, including high-quality randomized controlled trials.
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Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes
Our proof-of-concept study also constitutes the first trial of early time-restricted feeding (eTRF), a form of IF that involves eating early in the day to be in alignment with circadian rhythms in metabolism. Men with prediabetes were randomized to eTRF (6-hr feeding period, with dinner before 3 p.m.) or a control schedule (12-hr feeding period) for 5 weeks and later crossed over to the other schedule. eTRF improved insulin sensitivity, β cell responsiveness, blood pressure, oxidative stress, and appetite.
We demonstrate for the first time in humans that eTRF improves some aspects of cardiometabolic health and that IF’s effects are not solely due to weight loss.
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Human Performance Outliers Podcast (Shawn Baker & Zach Bitter)
Episode 2: Zach Bitter (Endurance althlete. World and American Record Holder - Three Time National Champion - World 100 km Team USA)
Episode 8: Owen Franks (Rugby. All Blacks)0 -
Another Nail in the Coffin for Fish Oil Supplements
All told, fish oil supplements did not reduce the risk of coronary heart disease deaths, nonfatal heart attacks, fatal or nonfatal strokes, revascularization procedures, or all-cause mortality among the full study population. The supplements also didn’t protect against major vascular events in any subgroups, including people with a history of heart disease, diabetes, high cholesterol, or statin use.
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It looks like Tom Naughton's new movie based on his Fat Heads Kids book is done. He uploaded a couple of the "chapters" to youtube.
Blog: Sneak Peeks: Fat Head Kids, The Movie
Chapter two of the Fat Head Kids movie explains why getting fat is about chemistry, not character. Your body's chief engineer (named Marty Metabolism in the film) responds to chemical messages exactly as he was programmed to respond.
Chapter four: How the Fuel System Works The human body is a biological starship named The Nautilus. This chapter explains how the fuel system works. Later chapters explain how a bad diet causes the fuel system to malfunction.0 -
Don't know if there is anything new in here, but a lot of resources in one place:
https://www.ketovale.com/low-carb-keto-diet-studies-list/0 -
Ketogenic Diets, Caloric Restriction, and Hormones
L. Amber O'Hearn
Two alternate hypotheses regarding the ketogenic diet are contrasted by the supposition of the first that ketosis is a stressor, mimicking starvation, whilst the second hypothesis posits that ketosis is natural and safe, attenuating evolutionary mismatch of the modern, post-agricultural diet.
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Modified ketogenic diet in lymphoma: A case series in the Veteran Affairs Pittsburgh Healthcare System.
Methods: Three lymphoma patients began the modified ketogenic diet. We provided dietary advice, limited daily carbohydrate to 20-40 grams, omitted sweets and starches. Data on their history, dietary course and clinical outcomes are presented.
Conclusions: Ketogenic diets in human lymphomas appears well tolerated and can improve symptoms, quality of life, and possibly limit tumors. Ketogenic diets may reverse the weight loss seen in terminal cancer patients with cachexia.
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Always liked Amber O'Hearn. She's realistic in discussing what keto may or may not do for people. Very honest.
Thanks for the lymphoma/cancer link too. I was just discussing similar thoughts on this yesterday, and bemoaning the lack of human evidence in supplementing cancer treatment and reducing cachexia with low carb diets.
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Re: Gary Taubes & Peter Attia's NuSi
The Collapse of a $40 Million Nutrition Science Crusade
by Megan Molteni
It could just be the jet lag, or it could be the mental burden of having to sing for his supper, but Taubes sounds tired. “I say this to my wife all the time: ‘Maybe I’m a quack.’ All quacks are sure they’re right. Isn’t that the defining characteristic of a quack? But the fact is that we funded four studies and the three randomized trials were highly successful operationally. One of these has been published in a top journal with interesting results and I remain hopeful that we will soon see if the last two studies will move some needles. Our convictions have gotten us this far, and despite some disappointments these questions still seem vitally important to test.”
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AlabasterVerve wrote: »Re: Gary Taubes & Peter Attia's NuSi
The Collapse of a $40 Million Nutrition Science Crusade
by Megan Molteni
It could just be the jet lag, or it could be the mental burden of having to sing for his supper, but Taubes sounds tired. “I say this to my wife all the time: ‘Maybe I’m a quack.’ All quacks are sure they’re right. Isn’t that the defining characteristic of a quack? But the fact is that we funded four studies and the three randomized trials were highly successful operationally. One of these has been published in a top journal with interesting results and I remain hopeful that we will soon see if the last two studies will move some needles. Our convictions have gotten us this far, and despite some disappointments these questions still seem vitally important to test.”
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Interesting.. not surprising, but interesting.2 -
Yeah... not surprising. Too bad though.1
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AlabasterVerve wrote: »
Another 10 years and maybe doctors and the public will start to accept this.
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AlabasterVerve wrote: »
Another 10 years and maybe doctors and the public will start to accept this.Is it reasonable to think that a response that mainly occurs in healthy people is a cause of disease?
Not a study, but my own experience is that I had low HDL levels when I was very overweight - low to the extent of taking Simvastatin and still seeing levels in the 30's. As I lost weight, that didn't change... until I started eating low carb. At that point, HDL progressively improved to where I no longer take Simvastatin and my last HDL test was in the 80's.
In the meantime, after going low carb, LDL decreased dramatically at first. The lowest was down to 17! Now that I'm only eating meat, it has risen to 120's and my dr. is concerned this is too high... despite that HDL is 80's on the same day. I'm not quite the healthiest I've ever been, but pretty dang close. So I figure it is not worth worrying about unless it gets much higher than that.0 -
midwesterner85 wrote: »AlabasterVerve wrote: »
Another 10 years and maybe doctors and the public will start to accept this.Is it reasonable to think that a response that mainly occurs in healthy people is a cause of disease?
Not a study, but my own experience is that I had low HDL levels when I was very overweight - low to the extent of taking Simvastatin and still seeing levels in the 30's. As I lost weight, that didn't change... until I started eating low carb. At that point, HDL progressively improved to where I no longer take Simvastatin and my last HDL test was in the 80's.
In the meantime, after going low carb, LDL decreased dramatically at first. The lowest was down to 17! Now that I'm only eating meat, it has risen to 120's and my dr. is concerned this is too high... despite that HDL is 80's on the same day. I'm not quite the healthiest I've ever been, but pretty dang close. So I figure it is not worth worrying about unless it gets much higher than that.
It's interesting how diet affects cholesterol!
cholesterol levels are interesting but I think they give it too much credit. It's treated like a cause of CVD but there is just some correlation with CVD with some types of cholesterol in some populations.
High Cholesterol appears in some CVD but it doesn't cause CVD. I just think they approach it in an unfortunate way.2
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