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Gut Microbiome impact on Health and Fitness
GaleHawkins
Posts: 8,159 Member
in Debate Club
What are the gut microbiota and human microbiome?
https://www.medicalnewstoday.com/articles/307998.php
[url="httphttps://www.medicalnewstoday.com/articles/323129.php://"]
[/url]
How a protein works with gut bacteria to prevent obesity
"Obesity is linked to higher levels of inflammation in the body, but the underlying mechanisms have remained unclear. Recently, however, a team of researchers has learned how one anti-inflammatory protein influences weight gain."
" "Obesity is influenced by inflammation, not just by overeating and lack of exercise, and this study suggests that reducing inflammation promotes 'good' bacteria that can help maintain a healthy weight," explains senior study author Jenny P-Y Ting.
"At the same time, the knockout mice lost numbers of Lachnospiraceae, which is a type of good gut bacteria that helps counteract inflammation and competes with Erysipelotrichaceae, curbing their spread.
Lachnospiraceae, the researchers explain, also appear to have a protective effect against insulin resistance and obesity in mice.
"All the inflammatory and metabolic changes we had seen in the NLRP12-knockout mice during a high-fat diet were essentially reversed when we resupplied Lachnospiraceae," explains Truax.
The results may lead to better ways of addressing obesity, the scientists add; Lachnospiraceae produce short-chain fatty acids, a type of molecule that plays an important role in metabolic processes. Two of these are butyrate and propionate, which also possess important anti-inflammatory properties."
https://www.medicalnewstoday.com/articles/307998.php
[url="httphttps://www.medicalnewstoday.com/articles/323129.php://"]
[/url]
How a protein works with gut bacteria to prevent obesity
"Obesity is linked to higher levels of inflammation in the body, but the underlying mechanisms have remained unclear. Recently, however, a team of researchers has learned how one anti-inflammatory protein influences weight gain."
" "Obesity is influenced by inflammation, not just by overeating and lack of exercise, and this study suggests that reducing inflammation promotes 'good' bacteria that can help maintain a healthy weight," explains senior study author Jenny P-Y Ting.
"At the same time, the knockout mice lost numbers of Lachnospiraceae, which is a type of good gut bacteria that helps counteract inflammation and competes with Erysipelotrichaceae, curbing their spread.
Lachnospiraceae, the researchers explain, also appear to have a protective effect against insulin resistance and obesity in mice.
"All the inflammatory and metabolic changes we had seen in the NLRP12-knockout mice during a high-fat diet were essentially reversed when we resupplied Lachnospiraceae," explains Truax.
The results may lead to better ways of addressing obesity, the scientists add; Lachnospiraceae produce short-chain fatty acids, a type of molecule that plays an important role in metabolic processes. Two of these are butyrate and propionate, which also possess important anti-inflammatory properties."
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Replies
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While it will soon be 5 years since I started the Keto WOE and it has done so much for disease state reversals in my case I knew ketones did not likely explain all of my health improvements that started long before I lost the first pound of weight. With a strong science background in the process of learning my OD degree back in 1986 and have been reading medical research since 1976 when I was told I had Ankylosing Spondylitis I could not buy into Keto being magical because magical happens for a concrete REASONS in my view and experience now at the age of 68.
When years of gut microbiome research hit critical mass (started making healthcare new feeds) recently I understood the "magic" behind my health improvements after I stopped eating any form of any sweeteners and or any form of any grains back in Oct 2014 hoping for pain management. Our gut microbiome seems to become our health partner or enemy based on what we feed it.
It may be another 20-30 years before Bill, John, David, Mary, Jane and Sue's of the world hear this from their doctor but I think we are moving into a new age where we treat the body to be naturally health instead of waiting and just treating the symptoms of disease states after the fact.
Those with a driving concern for better health and fitness are starting to get the basic science behind better health and fitness. We need to keep in mind there is no one Way Of Eating that works for everyone but in time I think most can find one WOE or more that gives them better health and fitness.28 -
The Gut Microbiome in Multiple Sclerosis: A Potential Therapeutic Avenue
https://ncbi.nlm.nih.gov/pmc/articles/PMC6163724/
The role of gut microbiome and associated metabolome in the regulation of neuroinflammation in multiple sclerosis and its implications in attenuating chronic inflammation in other inflammatory and autoimmune disorders.
https://ncbi.nlm.nih.gov/pubmed/2939273319 -
Autism symptoms reduced nearly 50 percent two years after fecal transplant
https://sciencedaily.com/releases/2019/04/190409093725.htm
"In a new study, "Long-term benefit of Microbiota Transfer Therapy in Autism Symptoms and Gut Microbiota," published in Scientific Reports, Arizona State University researchers Rosa Krajmalnik-Brown, Ph.D., James Adams, Ph.D, and lead author Dae-Wook Kang, Ph.D, demonstrate long-term beneficial effects for children diagnosed with ASD through a revolutionary technique known as Microbiota Transfer Therapy (MTT), a special type of fecal transplant originally pioneered by Dr. Thomas Borody, an Australian gastroenterologist. Remarkably, improvements in gut health and autism symptoms appear to persist long after treatment.
At two years post-treatment, most of the initial improvements in gut symptoms remained. In addition, parents reported a slow steady reduction of ASD symptoms during treatment and over the next two years. A professional evaluator found a 45% reduction in core ASD symptoms (language, social interaction and behavior) at two years post-treatment compared to before treatment began.
"We are finding a very strong connection between the microbes that live in our intestines and signals that travel to the brain," said Krajmalnik-Brown, a professor at the Biodesign Swette Center for Environmental Biotechnology at the Biodesign Institute and ASU's School for Sustainable Engineering and the Built Environment. "Two years later, the children are doing even better, which is amazing."
"Many kids with autism have gastrointestinal problems, and some studies, including ours, have found that those children also have worse autism-related symptoms," said Krajmalnik-Brown. "In many cases, when you are able to treat those gastrointestinal problems, their behavior improves."
Roughly 30-50% of all people with autism have chronic gastrointestinal (GI) problems, primarily constipation and/or diarrhea that can last for many years. That chronic discomfort and pain can cause irritability, decreased attention and learning, and negatively impact behavior.
An earlier study with only vancomycin (an antibiotic) had found major temporary improvements in GI and autism symptoms, but the benefits were lost a few weeks after treatment stopped despite use of over-the-counter probiotics.
So, the question at hand was what's going on in the gut, and how does it affect both physical and behavioral symptoms of autism, and how can we develop a long-lasting treatment?
Krajmalnik-Brown, Kang and Adams have shown that by transferring healthy microbiota to individuals lacking certain gut bacteria, it is possible to "donate" a more diverse set of bacteria into the patient and improve gut health.
In Australia, Fecal Microbiota Transplantation (FMT) was initially developed by Borody. At his Centre for Digestive Diseases in Sydney, Borody has overseen more than 18,000 FMTs for various disorders since 1987. He pioneered in Australia the use of FMT for colitis and Clostridium difficile infection, and was the first to use oral FMT to treat children with ASD. Only one dose of FMT is usually enough to cure C. Difficile infections, but his patients with autism were far harder to treat. He discovered that three months of daily FMT was required to treat his autism patients, but eventually resulted in significant improvements in both GI and autism symptoms.
Based on his experience with his patients, Borody led the design of the clinical treatment used at ASU for this study....."
CHILD’S RISK OF AUTISM CAN CHANGE BASED ON HEALTH OF MOTHER’S GUT
https://newsweek.com/autism-gut-health-signs-prevention-pregnancy-women-1031661
"New research suggests that the risk of developing autism is determined by the mother’s gut during pregnancy.
Scientists at the University of Virginia School of Medicine were able to analyze pregnant women’s microbiomes to determine the child’s risk of developing autism. The study, published July 2 in The Journal of Immunology, also researched how to use this finding to halt the development of autism-like neurodevelopmental disorders in mice.
“Our study was interested in understanding how the microbiome, which is the community of microbes that live within our gut, can shift susceptibility to autism-spectrum disorder,” John Lukens, assistant professor at the University of Virginia and lead author on the study, told Newsweek. To do this, the team studied, in part, interleukin-17a.
“It’s kind of the middleman between the gut and the brain,” Lukens says. Scientists at the Massachusetts Institute of Technology found that the inflammatory molecule interleukin-17a, or IL-17a, can influence the development of autism-like disorders in the brain. IL-17a has also been found to influence the development of multiple sclerosis and rheumatoid arthritis.
“What it can do during pregnancy is alter how the brain is developed and wired,” Lukens explains..... "27 -
The Microbiome and Weight Gain: Everything We Know So Far
https://viome.com/blog/microbiome-and-weight-gain-everything-we-know-so-far
".....Until recently, obesity was only associated with an individual’s food choices. This implied that obesity was a matter of choice alone.
Recent studies say that there may be more to obesity than a simple choice. Researchers examined the gut microbiome of obese and non-obese individuals. They found that the gut microbiome of obese and non-obese individuals is different. This difference dictates how the body uses energy from the food we consume. It also indicates that obesity is not just a matter of food choices. It is instead a matter of how gut bacteria process that food. This shifts how we look at obesity, as a disease rather than a consequence of poor food choices....."20 -
The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It
https://ncbi.nlm.nih.gov/pmc/articles/PMC5876658/16 -
GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.14 -
NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
Im trying to picture what a fecal transplant is.7 -
NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.21 -
NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
Im trying to picture what a fecal transplant is.
Here is one trustworthy source about FMT procedures.
https://hopkinsmedicine.org/gastroenterology_hepatology/clinical_services/advanced_endoscopy/fecal_transplantation.html
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GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
You're asking me how a prediction I made about a possible future is factual? Really?
For the record, Bill Gates is an Aspie. The guy who invented the concept of bit torrents is an Aspie, too; he had an insight about how data moves through the cloud based on how bees swam, and basically dropped everything until he saw his idea through. At Microsoft we have a team whose job it is to hire autistic devs and testers, because it's good business. The "interview" lasts two weeks, it's set up like a coding camp, applicants get to play with all kinds of cool technology and talk about what they like and what they can imagine.
But, sure, sticking other people's poop inside humans sounds like a great future too.
18 -
NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
You're asking me how a prediction I made about a possible future is factual? Really?
For the record, Bill Gates is an Aspie. The guy who invented the concept of bit torrents is an Aspie, too; he had an insight about how data moves through the cloud based on how bees swam, and basically dropped everything until he saw his idea through. At Microsoft we have a team whose job it is to hire autistic devs and testers, because it's good business. The "interview" lasts two weeks, it's set up like a coding camp, applicants get to play with all kinds of cool technology and talk about what they like and what they can imagine.
But, sure, sticking other people's poop inside humans sounds like a great future too.
No. I was just asking for info that showed the validity of your post.10 -
https://sciencenews.org/article/gut-bacteria-may-change-way-many-drugs-work-body
Gut bacteria may change the way many drugs work in the body
New research could help doctors choose medications for patients based on their microbiota9 -
NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
You're asking me how a prediction I made about a possible future is factual? Really?
For the record, Bill Gates is an Aspie. The guy who invented the concept of bit torrents is an Aspie, too; he had an insight about how data moves through the cloud based on how bees swam, and basically dropped everything until he saw his idea through. At Microsoft we have a team whose job it is to hire autistic devs and testers, because it's good business. The "interview" lasts two weeks, it's set up like a coding camp, applicants get to play with all kinds of cool technology and talk about what they like and what they can imagine.
But, sure, sticking other people's poop inside humans sounds like a great future too.
The procedure reduces the symptoms that are currently recognized as part of the autism diagnosis - speech issues, behavioral issues, social issues. It doesn't change a person's ability to create or imagine, it merely helps with the barriers that a lot of people with autism face. Many of the "famous ASD individuals" who we hear about also became famous from something they worked on individually or with a close friend or colleague, not as part of a larger organization, because the symptoms can make it difficult to get hired or keep a job in an environment that is built around neurotypical behavior being acceptable and expected.
I'm not sure how a procedure that could reduce the symptoms and allow the creative part of flourish more effectively would reduce our progress in any area.14 -
I love this thread. Nice work posting this, so much useful info.
20 -
This is all very interesting. My husband and daughter both have ADHD and my daughter shows signs of possible ASD, we are doing testing. I'm diagnosed with Irritable Bowel Disease (IBD) Ulcerative Colitis (UC) and Irritable Bowel Syndrome (IBS). I suffered with stomach issues since I was a baby and diagnosed in my early 20s with IBD and IBS. I was in remission when I got pregnant with my daughter but I wonder if I had taken a strong probiotic before and during my pregnancy what might have been the results? Would it have made a difference in her ADHD or possible ASD? I currently take a prescription probiotic that is designed for people with IBD/UC, I have also modified my diet to Autoimmune Paleo (AIP) and I feel better and more stable. Anyways my husband and I have been considering another pregnancy so I want to learn as much as possible about gut health and anything I can do to improve it. Thank you for sharing.10
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@MariahMichaels after I cut out added sugar and any form of any grain that morphed into a Keto Way Eating my arthritis pain after the first couple of weeks started decreasing fast as did my cravings for high sugar high fat foods so going to a low carb high fat WOE just happened without really even understanding what Keto was.
My body and mind was questioning how at my age that Keto could reverse so many of my health issues since 2014 just due to ketones. Now I understand in my case my new WOE was shifting my gut microbiome leading to resolving health issues in ways I never thought possible. Key I think is finding the Way Of Eating whatever it may be to enhance one's gut microbiome is Job One to better health now and later.
Your story is impressive so keep up the good work and best of success with your plans.21 -
NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
Im trying to picture what a fecal transplant is.
Fecal transplants are actually used as treatments for c diff, though it's not the first line of treatment from what I understand.
https://www.hopkinsmedicine.org/gastroenterology_hepatology/clinical_services/advanced_endoscopy/fecal_transplantation.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365524/5 -
GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.20 -
https://www.gastro.org/news/what-we-know-about-diet-and-the-gut-microbiome
https://anesthesiology.duke.edu/?p=846744 (On the American Gut Project)
"Diet. The number of plant types in a person’s diet plays a role in the diversity of his or her gut microbiome — the number of different types of bacteria living there. No matter the diet they prescribed to (vegetarian, vegan, etc.), participants who ate more than 30 different plant types per week (41 people) had gut microbiomes that were more diverse than those who ate 10 or fewer types of plants per week (44 people). The gut samples of these two groups also differed in the types of molecules present.
Antibiotics. The gut microbiomes of American Gut Project participants who reported that they took antibiotics in the past month (139 people) were, as predicted, less diverse than people who reported that they had not taken antibiotics in the last year (117 people). But, paradoxically, people who had taken antibiotics recently had significantly greater diversity in the types of chemicals in their gut samples than those who had not taken antibiotics in the past year.
The participants who ate more than 30 plants per week also had fewer antibiotic resistance genes in their gut microbiomes than people who ate 10 or fewer plants. In other words, the bacteria living in the guts of the plant-lovers had fewer genes that encode the molecular pumps that help the bacteria avoid antibiotics. This study didn’t address why this might be the case, but the researchers think it could be because people who eat fewer plants may instead be eating more meat from antibiotic-treated animals or processed foods with antibiotics added as a preservative, which may favor the survival of antibiotic-resistant bacteria.
Mental health. The American Gut Project researchers also examined the gut microbiomes of 125 people who reported having a mental health disorder, such as depression, schizophrenia, post-traumatic stress disorder (PTSD) or bipolar disorder. They matched each of these participants to individuals who did not have a mental health disorder, but did have other major factors in common, such as country, age, sex and body mass index. The team found that people with a mental disorder had more in common with other people with mental disorders, in terms of the bacteria makeup of their gut microbiomes, than they did with their mentally healthy pairs. The observation held true in both U.S. and UK populations, in males and females, and across age groups. In addition, the research team found some indications that specific bacteria types may be more common in people with depression than people who do not have the condition."
and
"Most of the findings emerging from the American Gut Project so far are simply observations or associations, and in many cases researchers can’t yet extrapolate the ultimate effect on human health. For example, while the researchers observed that people who eat many plants have a more diverse gut microbiome than those who don’t, they don’t yet know if increasing a person’s microbial diversity from its current level would have a direct positive effect on his or her health."
https://www.nytimes.com/2013/05/19/magazine/say-hello-to-the-100-trillion-bacteria-that-make-up-your-microbiome.html
"It is still early days in this research, as Lozupone (and everyone else I interviewed) underscored; scientists can’t even yet say with confidence exactly what a “healthy” microbiome should look like. But some broad, intriguing patterns are emerging. More diversity is probably better than less, because a diverse ecosystem is generally more resilient — and diversity in the Western gut is significantly lower than in other, less-industrialized populations. The gut microbiota of people in the West looks very different from that of a variety of other geographically dispersed peoples. So, for example, the gut community of rural people in West Africa more closely resembles that of Amerindians in Venezuela than it does an American’s or a European’s.
These rural populations not only harbor a greater diversity of microbes but also a different cast of lead characters. American and European guts contain relatively high levels of bacteroides and firmicutes and low levels of the prevotella that dominate the guts of rural Africans and Amerindians. (It is not clear whether high or low levels of any of these is good or bad.) Why are the microbes different? It could be the diet, which in both rural populations features a considerable amount of whole grains (which prevotella appear to like), plant fiber and very little meat. (Many firmicutes like amino acids, so they proliferate when the diet contains lots of protein; bacteroides metabolize carbohydrates.) As for the lower biodiversity in the West, this could be a result of our profligate use of antibiotics (in health care as well as the food system), our diet of processed food (which has generally been cleansed of all bacteria, the good and the bad), environmental toxins and generally less “microbial pressure” — i.e., exposure to bacteria — in everyday life. All of this may help explain why, though these rural populations tend to have greater exposures to infectious diseases and lower life expectancies than those in the West, they also have lower rates of chronic disorders like allergies, asthma, Type 2 diabetes and cardiovascular disease."
(But "may" -- it's important not to exaggerate what is known.)
12 -
GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
You're asking me how a prediction I made about a possible future is factual? Really?
For the record, Bill Gates is an Aspie. The guy who invented the concept of bit torrents is an Aspie, too; he had an insight about how data moves through the cloud based on how bees swam, and basically dropped everything until he saw his idea through. At Microsoft we have a team whose job it is to hire autistic devs and testers, because it's good business. The "interview" lasts two weeks, it's set up like a coding camp, applicants get to play with all kinds of cool technology and talk about what they like and what they can imagine.
But, sure, sticking other people's poop inside humans sounds like a great future too.
No. I was just asking for info that showed the validity of your post.
This is the most ironic thing I've read today. 17 -
NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
You're asking me how a prediction I made about a possible future is factual? Really?
For the record, Bill Gates is an Aspie. The guy who invented the concept of bit torrents is an Aspie, too; he had an insight about how data moves through the cloud based on how bees swam, and basically dropped everything until he saw his idea through. At Microsoft we have a team whose job it is to hire autistic devs and testers, because it's good business. The "interview" lasts two weeks, it's set up like a coding camp, applicants get to play with all kinds of cool technology and talk about what they like and what they can imagine.
But, sure, sticking other people's poop inside humans sounds like a great future too.
The procedure reduces the symptoms that are currently recognized as part of the autism diagnosis - speech issues, behavioral issues, social issues. It doesn't change a person's ability to create or imagine, it merely helps with the barriers that a lot of people with autism face. Many of the "famous ASD individuals" who we hear about also became famous from something they worked on individually or with a close friend or colleague, not as part of a larger organization, because the symptoms can make it difficult to get hired or keep a job in an environment that is built around neurotypical behavior being acceptable and expected.
I'm not sure how a procedure that could reduce the symptoms and allow the creative part of flourish more effectively would reduce our progress in any area.
Nonsense. These things are too interconnected. We don't (yet) have the ability to be as precise and selective as you're describing. If we did, no treatment would have side effects ever.
And autism doesn't work the way you seem to think it does.12 -
GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.15 -
NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.
Neither do some autistic people. My daughter will never be independent, marry, or do many of the things most people do. She can't even have a conversation. We would both be thrilled for there to be a treatment.
Absolutely, I too know some highly functional people on the spectrum who are fantastic and their characteristics make them who they are and proud of it. They should not have any treatment foisted on them. But, there's a large swath of people who are quite disabled an in desperate need of help.
ETA: That doesn't mean I hold high hopes in any of the info in this thread. Just was interested in what you were trying to say here.20 -
NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.
Neither do some autistic people. My daughter will never be independent, marry, or do many of the things most people do. She can't even have a conversation. We would both be thrilled for there to be a treatment.
Absolutely, I too know some highly functional people on the spectrum who are fantastic and their characteristics make them who they are and proud of it. They should not have any treatment foisted on them. But, there's a large swath of people who are quite disabled an in desperate need of help.
ETA: That doesn't mean I hold high hopes in any of the info in this thread. Just was interested in what you were trying to say here.
There's a saying, "if you know one autistic person ... you know one autistic person." Not all alike at all.
I'm sorry to hear about the effect it's had on your daughter's life. I hope she finds a lot of happiness in her day to day life.
🤗7 -
NorthCascades wrote: »NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.
Neither do some autistic people. My daughter will never be independent, marry, or do many of the things most people do. She can't even have a conversation. We would both be thrilled for there to be a treatment.
Absolutely, I too know some highly functional people on the spectrum who are fantastic and their characteristics make them who they are and proud of it. They should not have any treatment foisted on them. But, there's a large swath of people who are quite disabled an in desperate need of help.
ETA: That doesn't mean I hold high hopes in any of the info in this thread. Just was interested in what you were trying to say here.
There's a saying, "if you know one autistic person ... you know one autistic person." Not all alike at all.
I'm sorry to hear about the effect it's had on your daughter's life. I hope she finds a lot of happiness in her day to day life.
🤗
Thanks. Every day is an adventure!5 -
While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php
"Some drugs work well for one person but are ineffective for another; some also produce adverse events for certain individuals but not others. A study, using human gut bacteria and a mouse model, investigates whether our gut bacteria might help explain why."
"Scientists are now investigating gut bacteria's role in a diverse range of diseases, from Parkinson's disease to anxiety to heart disease.
Once an obscure niche of medical research, gut bacteria are now firmly in the spotlight."
"There are many reasons why people respond differently to the same drug, including age, sex, and diet. So, could the bacteria in our gut also be playing a role?
According to the latest team of researchers to look into this question, our microbiome contains 150 times more genes than our own genome. These microscopic tenants produce a wide array of enzymes, some of which can alter drugs, either activating them or rendering them ineffective."
"To investigate the interaction further, the scientists used gnotobiotic mice — animals free from microbes.
They found that 176 out of the 271 drugs (64.9%) could be metabolized by gut bacteria, reducing the drug's concentration significantly. They also showed that each strain of bacteria could metabolize 11–95 types of drug."
"In the future, it might be possible to modify a person's microbiome to ensure that a drug works effectively and reduce the risk of serious adverse events. However, scientists will need to carry out much more research to build up a clearer picture of how these interactions work.
For now, our understanding of the influence of gut bacteria and drug metabolism is still in its infancy. Nevertheless, the findings from this latest study make it seem likely that our gut bacteria are having at least some influence on the medicines we take."14 -
You know, it's really disappointing to see a "scientific" article without a references section. It also inspires absolutely no trust. It's not as if the people who purportedly write these articles are incapable of citing their sources in a responsible way - they have more than enough formal education.GaleHawkins wrote: »While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php11 -
You know, it's really disappointing to see a "scientific" article without a references section. It also inspires absolutely no trust. It's not as if the people who purportedly write these articles are incapable of citing their sources in a responsible way - they have more than enough formal education.GaleHawkins wrote: »While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php
What do you call this reference the writer cited in the article by a hyperlink?
https://nature.com/articles/s41586-019-1291-3
9 -
NorthCascades wrote: »NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
You're asking me how a prediction I made about a possible future is factual? Really?
For the record, Bill Gates is an Aspie. The guy who invented the concept of bit torrents is an Aspie, too; he had an insight about how data moves through the cloud based on how bees swam, and basically dropped everything until he saw his idea through. At Microsoft we have a team whose job it is to hire autistic devs and testers, because it's good business. The "interview" lasts two weeks, it's set up like a coding camp, applicants get to play with all kinds of cool technology and talk about what they like and what they can imagine.
But, sure, sticking other people's poop inside humans sounds like a great future too.
The procedure reduces the symptoms that are currently recognized as part of the autism diagnosis - speech issues, behavioral issues, social issues. It doesn't change a person's ability to create or imagine, it merely helps with the barriers that a lot of people with autism face. Many of the "famous ASD individuals" who we hear about also became famous from something they worked on individually or with a close friend or colleague, not as part of a larger organization, because the symptoms can make it difficult to get hired or keep a job in an environment that is built around neurotypical behavior being acceptable and expected.
I'm not sure how a procedure that could reduce the symptoms and allow the creative part of flourish more effectively would reduce our progress in any area.
Nonsense. These things are too interconnected. We don't (yet) have the ability to be as precise and selective as you're describing. If we did, no treatment would have side effects ever.
And autism doesn't work the way you seem to think it does.
I have a child with autism.4 -
GaleHawkins wrote: »
You know, it's really disappointing to see a "scientific" article without a references section. It also inspires absolutely no trust. It's not as if the people who purportedly write these articles are incapable of citing their sources in a responsible way - they have more than enough formal education.GaleHawkins wrote: »While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php
What do you call this reference the writer cited in the article by a hyperlink?
https://nature.com/articles/s41586-019-1291-3
Do you know what a references section is? From the nature of your reply it doesn't appear that you do because your reply is totally off the mark. It would be like someone asking, "do you know what a grocery list is" and you replying the word "cucumber". Except even then, "cucumber" could be on a grocery list, whereas I doubt simply listing a URL is an appropriate way to cite something in any commonly used citation standard (ex. APA).
edit: But to answer your question - I call that not a references section. I call it a link to an article.12
This discussion has been closed.
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