Why Aspartame Isn't Scary
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Some animal studies have showed it messing with the gut biome, even at normal consumption levels (not the absurd consumption levels you sometimes see in animal studies.)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109841
I'm cautious about my gut biome, I'd rather not take a substance that has been shown to mess with it if there's no good reason to take it (for example, yogurt can change your gut biome, but yogurt is delicious so I eat it anyway, antibiotics can wreck your gut biome, but if I got a gangrenous limb, hand me the antibiotics, please.)
The thing with animal studies is, they can at best give you an indication to look for something in people.
Chocolate or grapes will make a dog extremely sick but not people, just as a single example.4 -
stevencloser wrote: »Some animal studies have showed it messing with the gut biome, even at normal consumption levels (not the absurd consumption levels you sometimes see in animal studies.)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109841
I'm cautious about my gut biome, I'd rather not take a substance that has been shown to mess with it if there's no good reason to take it (for example, yogurt can change your gut biome, but yogurt is delicious so I eat it anyway, antibiotics can wreck your gut biome, but if I got a gangrenous limb, hand me the antibiotics, please.)
The thing with animal studies is, they can at best give you an indication to look for something in people.
Chocolate or grapes will make a dog extremely sick but not people, just as a single example.
The amount of chocolate that a dog has to consume in order to make it sick depends on its weight. A chihuahua will get very ill -- maybe even die -- if it eats a pound of chocolate. I'm pretty sure that I would be sick if I ingested a pound of chocolate. I give chocolate to my current dog. Gave it to my old dog. Old dog died of cancer at the age of 12. Current dog still alive.
Grapes were found to be poisonous to dogs when there was a pattern in sick dogs.
Do you even know why they do studies on mice? It's because their genetic, biological and behavior characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats. Also they're inexpensive and can be bought in large quantities.1 -
Sassie_Lassie wrote: »stevencloser wrote: »Some animal studies have showed it messing with the gut biome, even at normal consumption levels (not the absurd consumption levels you sometimes see in animal studies.)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109841
I'm cautious about my gut biome, I'd rather not take a substance that has been shown to mess with it if there's no good reason to take it (for example, yogurt can change your gut biome, but yogurt is delicious so I eat it anyway, antibiotics can wreck your gut biome, but if I got a gangrenous limb, hand me the antibiotics, please.)
The thing with animal studies is, they can at best give you an indication to look for something in people.
Chocolate or grapes will make a dog extremely sick but not people, just as a single example.
The amount of chocolate that a dog has to consume in order to make it sick depends on its weight. A chihuahua will get very ill -- maybe even die -- if it eats a pound of chocolate. I'm pretty sure that I would be sick if I ingested a pound of chocolate. I give chocolate to my current dog. Gave it to my old dog. Old dog died of cancer at the age of 12. Current dog still alive.
Grapes were found to be poisonous to dogs when there was a pattern in sick dogs.
Do you even know why they do studies on mice? It's because their genetic, biological and behavior characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats. Also they're inexpensive and can be bought in large quantities.
"The mouse is the most common model organism for preclinical studies even though it
has not proven particularly reliable at predicting the outcome of studies in humans. "
http://ec.europa.eu/research/health/pdf/summary-report-25082010_en.pdf
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stevencloser wrote: »Sassie_Lassie wrote: »stevencloser wrote: »Some animal studies have showed it messing with the gut biome, even at normal consumption levels (not the absurd consumption levels you sometimes see in animal studies.)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109841
I'm cautious about my gut biome, I'd rather not take a substance that has been shown to mess with it if there's no good reason to take it (for example, yogurt can change your gut biome, but yogurt is delicious so I eat it anyway, antibiotics can wreck your gut biome, but if I got a gangrenous limb, hand me the antibiotics, please.)
The thing with animal studies is, they can at best give you an indication to look for something in people.
Chocolate or grapes will make a dog extremely sick but not people, just as a single example.
The amount of chocolate that a dog has to consume in order to make it sick depends on its weight. A chihuahua will get very ill -- maybe even die -- if it eats a pound of chocolate. I'm pretty sure that I would be sick if I ingested a pound of chocolate. I give chocolate to my current dog. Gave it to my old dog. Old dog died of cancer at the age of 12. Current dog still alive.
Grapes were found to be poisonous to dogs when there was a pattern in sick dogs.
Do you even know why they do studies on mice? It's because their genetic, biological and behavior characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats. Also they're inexpensive and can be bought in large quantities.
"The mouse is the most common model organism for preclinical studies even though it
has not proven particularly reliable at predicting the outcome of studies in humans. "
http://ec.europa.eu/research/health/pdf/summary-report-25082010_en.pdf
Bingo. My impression is that mice are good enough considering how cheap they are, but certainly not ideal beyond cost.1 -
Sassie_Lassie wrote: »stevencloser wrote: »Some animal studies have showed it messing with the gut biome, even at normal consumption levels (not the absurd consumption levels you sometimes see in animal studies.)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109841
I'm cautious about my gut biome, I'd rather not take a substance that has been shown to mess with it if there's no good reason to take it (for example, yogurt can change your gut biome, but yogurt is delicious so I eat it anyway, antibiotics can wreck your gut biome, but if I got a gangrenous limb, hand me the antibiotics, please.)
The thing with animal studies is, they can at best give you an indication to look for something in people.
Chocolate or grapes will make a dog extremely sick but not people, just as a single example.
The amount of chocolate that a dog has to consume in order to make it sick depends on its weight. A chihuahua will get very ill -- maybe even die -- if it eats a pound of chocolate. I'm pretty sure that I would be sick if I ingested a pound of chocolate. I give chocolate to my current dog. Gave it to my old dog. Old dog died of cancer at the age of 12. Current dog still alive.
Grapes were found to be poisonous to dogs when there was a pattern in sick dogs.
Do you even know why they do studies on mice? It's because their genetic, biological and behavior characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats. Also they're inexpensive and can be bought in large quantities.
No, as someone who has done studies on rats when in grad school, they're actually pretty bad models.
The reason that they are used is because they are cheap, easy to raise, easy to do studies on, and there's no better animal that is as cost effective and will pass IRB scrutiny. If you wanted reliable animal studies, you'd basically have to use other great apes like chimpanzees, and besides being prohibitively expensive, try getting a review board to approve experimenting on an endangered species that is among the most intelligent and humanlike of animals.4 -
I wonder why they are changing the name to amino sweet? Thoughts?0
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rankinsect wrote: »Sassie_Lassie wrote: »stevencloser wrote: »Some animal studies have showed it messing with the gut biome, even at normal consumption levels (not the absurd consumption levels you sometimes see in animal studies.)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109841
I'm cautious about my gut biome, I'd rather not take a substance that has been shown to mess with it if there's no good reason to take it (for example, yogurt can change your gut biome, but yogurt is delicious so I eat it anyway, antibiotics can wreck your gut biome, but if I got a gangrenous limb, hand me the antibiotics, please.)
The thing with animal studies is, they can at best give you an indication to look for something in people.
Chocolate or grapes will make a dog extremely sick but not people, just as a single example.
The amount of chocolate that a dog has to consume in order to make it sick depends on its weight. A chihuahua will get very ill -- maybe even die -- if it eats a pound of chocolate. I'm pretty sure that I would be sick if I ingested a pound of chocolate. I give chocolate to my current dog. Gave it to my old dog. Old dog died of cancer at the age of 12. Current dog still alive.
Grapes were found to be poisonous to dogs when there was a pattern in sick dogs.
Do you even know why they do studies on mice? It's because their genetic, biological and behavior characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats. Also they're inexpensive and can be bought in large quantities.
No, as someone who has done studies on rats when in grad school, they're actually pretty bad models.
The reason that they are used is because they are cheap, easy to raise, easy to do studies on, and there's no better animal that is as cost effective and will pass IRB scrutiny. If you wanted reliable animal studies, you'd basically have to use other great apes like chimpanzees, and besides being prohibitively expensive, try getting a review board to approve experimenting on an endangered species that is among the most intelligent and humanlike of animals.
Last I heard nih had either stopped or was talking about not finding research on primates anymore. Those that have colonies can maintain their current animals, but they can't breed or buy new ones.
And IRBs are humans, it's the animal welfare committee that reviews animals (and their regulations are much stricter than IRBs since animals can't give voluntary consent).1 -
I don't drink fizzy drinks because they make me burp really loud for a good hour3
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I know it's old, but someone had this appear in my feed and I LOVE YOU @Aaron_K123Aaron_K123 wrote: »<<everything you said even though it's an old post>>
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They also use mice because their lifecycle and metabolic processes are faster so they are able to see long term effects of an exposure (on both the subject and its offspring) in a much shorter time. Again this is often very difficult to extrapolate in humans which is why saccharine was once named as a carcinogen due to its effects on rats, but disproven to be plausible in humans.4
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georgyporcupine wrote: »I don't drink fizzy drinks because they make me burp really loud for a good hour
this is a bad thing?0 -
georgyporcupine wrote: »I don't drink fizzy drinks because they make me burp really loud for a good hour
I think the later half of this would make an awesome pick up line.
I tend to avoid artificial sweeteners simply because I don't like the after taste. I'm not going to tell others they need to avoid it.0 -
stevencloser wrote: »Some animal studies have showed it messing with the gut biome, even at normal consumption levels (not the absurd consumption levels you sometimes see in animal studies.)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109841
I'm cautious about my gut biome, I'd rather not take a substance that has been shown to mess with it if there's no good reason to take it (for example, yogurt can change your gut biome, but yogurt is delicious so I eat it anyway, antibiotics can wreck your gut biome, but if I got a gangrenous limb, hand me the antibiotics, please.)
The thing with animal studies is, they can at best give you an indication to look for something in people.
Chocolate or grapes will make a dog extremely sick but not people, just as a single example.
Usually, you pick the animal model based on the mechanism you are interested in. Dogs cannot metabolize theobromine, whereas we humans can. For them, it builds up, and will produce a result similar to caffeine overdose in humans. If I'm interested in theobromine toxicity, I choose a dog, not a rat.
If you're interested in gut reactions, you choose pigs. If you're interested in eyes, choose rabbits or pigs. Each animal is chosen based on what you'd like to observe in a human-- then the animal model which most closely mimics that is chosen.0 -
Some animal studies have showed it messing with the gut biome, even at normal consumption levels (not the absurd consumption levels you sometimes see in animal studies.)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109841
I'm cautious about my gut biome, I'd rather not take a substance that has been shown to mess with it if there's no good reason to take it (for example, yogurt can change your gut biome, but yogurt is delicious so I eat it anyway, antibiotics can wreck your gut biome, but if I got a gangrenous limb, hand me the antibiotics, please.)
Out of curiosity in what way specifically are you "cautious" about *your* "gut biome"? What specific species of bacteria do you promote the growth of and how do you do so? In the study you quoted all of the different diets they provided caused shifts in the population of the animals gut microbiome, why are you focusing on aspartame? If you change your diet it is going to change your gut flora, that is true...but to assume that the change is "bad" in the case of aspartame while being "good" in the case of other foods is based on what exactly?
This idea that there is some "ideal" microbiome that is typically homeostatic regardless of your diet but is somehow disrupted specifically by aspartame is false. It is not what the study you cite says, it is not what any study says that I am aware of.
All "substances" "mess" with your gut biome. Your gut biome survives off of your diet and if you change your diet at all then your gut biome will adapt accordingly and change as well. This idea that there is some perfect "gut biome" that one must preserve by eating XYZ and avoiding ABC is just made-up and not based on anything we have actually studied or understood.15 -
Bumping1
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queenliz99 wrote: »Bumping
Great idea2 -
1
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diannethegeek wrote: »
Especially this past weekend1 -
Sounds like someone work for a soda company??
http://articles.mercola.com/sites/articles/archive/2011/11/06/aspartame-most-dangerous-substance-added-to-food.aspx
Since Monsanto is involved you know it can't be good.2 -
cruisercrawler wrote: »Sounds like someone work for a soda company??
http://articles.mercola.com/sites/articles/archive/2011/11/06/aspartame-most-dangerous-substance-added-to-food.aspx
Since Monsanto is involved you know it can't be good.
http://www.quackwatch.com/11Ind/mercola.html7
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